Negative immunohistochemical staining of p53 protein does not always reflect wild-type p53 gene in cancer cells

被引:4
|
作者
Horiuchi, H
Kawamata, H
Omotehara, F
Fujii, S
Fujimori, T
Kuroda, Y
机构
[1] Dokkyo Univ, Sch Med, Dept Surg & Mol Pathol, Shimo Tsuga, Tochigi 3210293, Japan
[2] Kobe Univ, Grad Sch Med Sci, Div Gastroenterol Surg, Dept Clin Mol Med, Kobe, Hyogo, Japan
关键词
D O I
10.1007/s00535-003-1378-2
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:801 / 803
页数:3
相关论文
共 50 条
  • [31] Osteocalcin Gene Expression Is Regulated by Wild-Type p53
    Hankui Chen
    Emily Hays
    Jay Liboon
    Chris Neely
    Kevin Kolman
    Nalini Chandar
    Calcified Tissue International, 2011, 89 : 411 - 418
  • [32] ACCUMULATION OF WILD-TYPE P53 IN MENINGIOMAS
    ELLISON, DW
    LUNEC, J
    GALLAGHER, PJ
    STEART, PV
    JAROS, E
    GATTER, KC
    NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY, 1995, 21 (02) : 136 - 142
  • [33] WILD-TYPE P53 SUPPRESSES GROWTH OF HUMAN PROSTATE-CANCER CELLS CONTAINING MUTANT P53 ALLELES
    ISAACS, WB
    CARTER, BS
    EWING, CM
    CANCER RESEARCH, 1991, 51 (17) : 4716 - 4720
  • [34] The Stapled Peptide PM2 Stabilizes p53 Levels and Radiosensitizes Wild-Type p53 Cancer Cells
    Mortensen, Anja Charlotte Lundgren
    Spiegelberg, Diana
    Brown, Christopher John
    Lane, David Philip
    Nestor, Marika
    FRONTIERS IN ONCOLOGY, 2019, 9
  • [35] WILD-TYPE P53 SUPPRESSES THE MALIGNANT PHENOTYPE IN BREAST-CANCER CELLS CONTAINING MUTANT P53 ALLELES
    RUNNEBAUM, IB
    YEE, JK
    KIEBACK, DG
    SUKUMAR, S
    FRIEDMANN, T
    ANTICANCER RESEARCH, 1994, 14 (3A) : 1137 - 1144
  • [36] ACCUMULATION OF WILD-TYPE P53 PROTEIN IN HUMAN ASTROCYTOMAS
    RUBIO, MP
    VONDEIMLING, A
    YANDELL, DW
    WIESTLER, OD
    GUSELLA, JF
    LOUIS, DN
    CANCER RESEARCH, 1993, 53 (15) : 3465 - 3467
  • [37] Retention of wild-type p53 in tumors from p53 heterozygous mice: reduction of p53 dosage can promote cancer formation
    Venkatachalam, S
    Shi, YP
    Jones, SN
    Vogel, H
    Bradley, A
    Pinkel, D
    Donehower, LA
    EMBO JOURNAL, 1998, 17 (16): : 4657 - 4667
  • [38] Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53
    Lu, Phong
    Vander Mause, Erica R.
    Bowman, Katherine E. Redd
    Brown, Sarah M.
    Ahne, Lisa
    Lim, Carol S.
    JOURNAL OF OVARIAN RESEARCH, 2019, 12 (1)
  • [39] Mitochondrially targeted p53 or DBD subdomain is superior to wild type p53 in ovarian cancer cells even with strong dominant negative mutant p53
    Phong Lu
    Erica R. Vander Mause
    Katherine E. Redd Bowman
    Sarah M. Brown
    Lisa Ahne
    Carol S. Lim
    Journal of Ovarian Research, 12
  • [40] Targeted point mutations of p53 lead to dominant-negative inhibition of wild-type p53 function
    de Vries, A
    Flores, ER
    Miranda, B
    Hsieh, HM
    van Oostrom, CTM
    Sage, J
    Jacks, T
    PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2002, 99 (05) : 2948 - 2953