In vivo evidence of differential impact of typical and atypical antipsychotics on intracortical myelin in adults with schizophrenia

被引：78

作者：

Bartzokis, George ^{[1
,2
,3
]}

Lu, Po H.

Stewart, Stephanie B. ^{[1
]}

Oluwadara, Bolanle ^{[1
,3
]}

Lucas, Andrew J. ^{[1
]}

Pantages, Joanna ^{[1
,3
]}

Pratt, Erika ^{[1
,3
]}

Sherin, Jonathan E. ^{[1
,3
]}

Altshuler, Lori L. ^{[1
,3
]}

Mintz, Jim ^{[4
]}

Gitlin, Michael J. ^{[1
]}

Subotnik, Kenneth L. ^{[1
]}

Nuechterlein, Keith H. ^{[1
]}

机构：

[1] Univ Calif Los Angeles, David Geffen Sch Med, Dept Psychiat & Behav Sci, Los Angeles, CA 90095 USA

[2] Univ Calif Los Angeles, David Geffen Sch Med, Dept Neurol, Div Brain Mapping,Lab Neuroimaging, Los Angeles, CA 90095 USA

[3] Greater Los Angeles VA Healthcare Syst, Los Angeles, CA USA

[4] Univ Texas Hlth Sci Ctr San Antonio, Dept Epidemiol & Biostat, San Antonio, TX 78229 USA

来源：

SCHIZOPHRENIA RESEARCH | 2009年 / 113卷 / 2-3期

基金：

美国国家卫生研究院;

关键词：

Schizophrenia; Second generation antipsychotic medication; Atypical; Intracortical myelin; White matter; Gray matter; Oligodendrocyte; Trajectory; Development; Lipid; Age; Prevention; DORSOLATERAL PREFRONTAL CORTEX; INCREASES CELL-PROLIFERATION; MATTER STRUCTURAL INTEGRITY; WHITE-MATTER; BIPOLAR DISORDER; GRAY-MATTER; HIPPOCAMPAL-FORMATION; MORPHOMETRIC ANALYSIS; NEUREGULIN-1; GENE; BRAIN MYELINATION;

D O I：

10.1016/j.schres.2009.06.014

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Context: Imaging and post-mortem studies provide converging evidence that patients with schizophrenia have a dysregulated developmental trajectory of frontal lobe myelination. The hypothesis that typical and atypical medications may differentially impact brain myelination in adults with schizophrenia was previously assessed with inversion recovery (IR) images. Increased white matter (WM) volume suggestive of increased myelination was detected in the patient group treated with an atypical antipsychotic compared to a typical one. Objective: In a follow-up reanalysis of MRI images from the original study, we used a novel method to assess whether the difference in WM volumes could be caused by a differential effect of medications on the intracortical myelination process. Design, setting, and participants: Two different male cohorts of healthy controls ranging in age from 18-35 years were compared to cohorts of subjects with schizophrenia who were treated with either oral risperidone (Ris) or fluphenazine decanoate (Fd). Main outcome measure: A novel MRI method that combines the distinct tissue contrasts provided by IR and proton density (PD) images was used to estimate intracortical myelin (ICM) volume. Results: When compared with their pooled healthy control comparison group, the two groups of schizophrenic patients differed in the frontal lobe ICM measure with the Ris group having significantly higher volume. Conclusions: The data suggest that in adults with schizophrenia antipsychotic treatment choice may be specifically and differentially impacting later-myelinating intracortical circuitry. In vivo MRI can be used to dissect subtle differences in brain tissue characteristics and thus help clarify the effect of pharmacologic treatments on developmental and pathologic processes. (C) 2009 Elsevier B.V. All rights reserved.

引用

页码：322 / 331

页数：10

共 111 条

[1] Normal neuroanatomical variation due to age: The major lobes and a parcellation of the temporal region [J].