Sexual dimorphic expression of mouse hepatic CYP2B: alterations during development or after hypophysectomy

被引：16
作者：
Jarukamjorn, K [1 ]
Sakuma, T [1 ]
Nemoto, N [1 ]
机构：
[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Toxicol, Sugitani, Toyama 2630, Japan
来源：
BIOCHEMICAL PHARMACOLOGY | 2002年 / 63卷 / 11期
关键词：
CYP2B; hypophysectomy; sex hormones; development; sexual dimorphism; expression;
D O I：
10.1016/S0006-2952(02)00989-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The constitutive expression of CYP2B mRNA in the livers of mice in the prepubertal stage was sex-independent, with CYP2B9 as the principal isoform. During the maturation stage, CYP2B10 was expressed in both sexes, whereas CYP2B9 was diminished markedly in the males, resulting in a sexually dimorphic expression in adult mice. Hypophysectomy eliminated the sexual dimorphism in the mouse CYP2B subfamily by markedly increasing the expression of both CYP2B9 and CYP2B10 in males to levels similar to those in females. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：2037 / 2041
页数：5
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