Sexual dimorphic expression of mouse hepatic CYP2B: alterations during development or after hypophysectomy

被引：16
作者：
Jarukamjorn, K [1 ]
Sakuma, T [1 ]
Nemoto, N [1 ]
机构：
[1] Toyama Med & Pharmaceut Univ, Fac Pharmaceut Sci, Dept Toxicol, Sugitani, Toyama 2630, Japan
来源：
BIOCHEMICAL PHARMACOLOGY | 2002年 / 63卷 / 11期
关键词：
CYP2B; hypophysectomy; sex hormones; development; sexual dimorphism; expression;
D O I：
10.1016/S0006-2952(02)00989-9
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The constitutive expression of CYP2B mRNA in the livers of mice in the prepubertal stage was sex-independent, with CYP2B9 as the principal isoform. During the maturation stage, CYP2B10 was expressed in both sexes, whereas CYP2B9 was diminished markedly in the males, resulting in a sexually dimorphic expression in adult mice. Hypophysectomy eliminated the sexual dimorphism in the mouse CYP2B subfamily by markedly increasing the expression of both CYP2B9 and CYP2B10 in males to levels similar to those in females. (C) 2002 Elsevier Science Inc. All rights reserved.
引用
收藏
页码：2037 / 2041
页数：5
相关论文
共 20 条
  • [1] Chang TKH, 1997, DRUG METAB DISPOS, V25, P994
  • [2] DANNAN GA, 1986, J BIOL CHEM, V261, P728
  • [3] STAT5b-deficient mice are growth hormone pulse-resistant - Role of STAT5b in sex-specific liver P450 expression
    Davey, HW
    Park, SH
    Grattan, DR
    McLachlan, MJ
    Waxman, DJ
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (50) : 35331 - 35336
  • [4] Different regulation of the expression of mouse hepatic cytochrome P4502B enzymes by glucocorticoid and phenobarbital
    Jarukamjorn, K
    Sakuma, T
    Miyaura, JI
    Nemoto, N
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1999, 369 (01) : 89 - 99
  • [5] Sex-associated expression of mouse hepatic and renal CYP2B enzymes by glucocorticoid hormones
    Jarukamjorn, K
    Sakuma, T
    Yamamoto, M
    Ohara, A
    Nemoto, N
    [J]. BIOCHEMICAL PHARMACOLOGY, 2001, 62 (02) : 161 - 169
  • [6] Discriminating activation of CYP2B9 expression in male C57BL/6 mouse liver by β-estradiol
    Jarukamjorn, K
    Sakuma, T
    Nemoto, N
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2000, 279 (01) : 288 - 292
  • [7] Estrogen activation of the nuclear orphan receptor CAR (Constitutive active receptor) in induction of the mouse Cyp2b10 gene
    Kawamoto, T
    Kakizaki, S
    Yoshinari, K
    Negishi, M
    [J]. MOLECULAR ENDOCRINOLOGY, 2000, 14 (11) : 1897 - 1905
  • [8] SEX-DIFFERENCES IN THE ULTRADIAN PATTERN OF PLASMA GROWTH-HORMONE CONCENTRATIONS IN MICE
    MACLEOD, JN
    PAMPORI, NA
    SHAPIRO, BH
    [J]. JOURNAL OF ENDOCRINOLOGY, 1991, 131 (03) : 395 - 399
  • [9] REGULATION OF PHENOBARBITAL-INDUCIBLE CYTOCHROME-P-450S IN RAT AND MOUSE-LIVER FOLLOWING DEXAMETHASONE ADMINISTRATION AND HYPOPHYSECTOMY
    MEEHAN, RR
    FORRESTER, LM
    STEVENSON, K
    HASTIE, ND
    BUCHMANN, A
    KUNZ, HW
    WOLF, CR
    [J]. BIOCHEMICAL JOURNAL, 1988, 254 (03) : 789 - 797
  • [10] GLUCOCORTICOID AND SEX-HORMONES AS ACTIVATING OR MODULATING FACTORS FOR EXPRESSION OF CYP2B-9 AND CYP2B-L0 IN THE MOUSE-LIVER AND HEPATOCYTES
    NEMOTO, N
    SAKURAI, J
    [J]. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1995, 319 (01) : 286 - 292
12