Treatment options for epileptic myoclonus and epilepsy syndromes associated with myoclonus

被引：4

作者：

Andrade, Danielle M. ^{[2
]}

Hamani, Clement ^{[2
]}

Minassian, Berge A. ^{[1
]}

机构：

[1] Univ Toronto, Hosp Sick Children, Dept Pediat, Div Neurol, Toronto, ON M5G 1X8, Canada

[2] Univ Toronto, Toronto Western Hosp, Div Neurol, Krembil Neurosci Ctr, Toronto, ON M5T 2S8, Canada

来源：

EXPERT OPINION ON PHARMACOTHERAPY | 2009年 / 10卷 / 10期

关键词：

deep brain stimulation; ketogenic diet; myoclonic seizures; myoclonus; progressive myoclonus epilepsy; treatment; VAGUS-NERVE-STIMULATION; IDIOPATHIC GENERALIZED EPILEPSY; UNVERRICHT-LUNDBORG-DISEASE; LENNOX-GASTAUT-SYNDROME; DEEP BRAIN-STIMULATION; LONG-TERM OBSERVATIONS; ADD-ON THERAPY; CORPUS CALLOSOTOMY; CLINICAL-EXPERIENCE; ANTIEPILEPTIC DRUGS;

D O I：

10.1517/14656560903025189

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background: Myoclonus is a brief shock-like movement that has many different etiologies. The degree to which it disturbs quality of life is extremely variable, as is its response to treatment. Objective: In this review, we focus on the treatment strategies for epileptic myoclonus in some common disorders, and in others that are not so common but where myoclonus is a prominent feature and has been studied more. Methods: An extended literature review in the English language was conducted through PubMed and text books. Conclusion: Epileptic myoclonus is a manifestation of cortical irritability. The precise etiology is important when determining the best course of treatment. Response to treatment is variable and usually depends on the epileptic syndrome. Some antiepileptic drugs may worsen myoclonus even in patients with syndromes where most patients have a good response to that same drug. Therefore, clinicians must always have in mind that worsening in myoclonus may be ameliorated by decrease or withdrawal rather than increase of medication.

引用

页码：1549 / 1560

页数：12

共 137 条

[1] Lamotrigine therapy in infantile neuronal ceroid lipofuscinosis (INCL) [J].

Aberg, L ;

Heiskala, H ;

Vanhanen, SL ;

Himberg, JJ ;

Hosking, G ;

Yuen, A ;

Santavuori, P .

NEUROPEDIATRICS, 1997, 28 (01) :77-79

[2] Epilepsy and antiepileptic drug therapy in juvenile neuronal ceroid lipofuscinosis [J].

Åberg, LE ;

Bäckman, M ;

Kirveskari, E ;

Santavuori, P .

EPILEPSIA, 2000, 41 (10) :1296-1302

[3] Long-term multicenter experience with vagus nerve stimulation for intractable partial seizures - Results of the XE5 trial [J].

Amar, AP ;

DeGiorgio, CM ;

Tarver, WB ;

Apuzzo, MLJ .

STEREOTACTIC AND FUNCTIONAL NEUROSURGERY, 1999, 73 (1-4) :104-108

[4]

Andrade D M, 2007, Acta Myol, V26, P83

[5] EYELID MYOCLONIA WITH TYPICAL ABSENCES - AN EPILEPSY SYNDROME [J].

APPLETON, RE ;

PANAYIOTOPOULOS, CP ;

ACOMB, BA ;

BEIRNE, M .

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1993, 56 (12) :1312-1316

[6] Vagus nerve stimulation for medically refractory epilepsy: A long-term follow-up study [J].

Ardesch, J. J. ;

Buschman, H. P. J. ;

Wagener-Schimmel, L. J. J. C. ;

van der Aa, H. E. ;

Hageman, G. .

SEIZURE-EUROPEAN JOURNAL OF EPILEPSY, 2007, 16 (07) :579-585

[7] Corpus callosotomy [J].

Asadi-Pooya, Ali A. ;

Sharan, Ashwini ;

Nei, Maromi ;

Sperling, Michael R. .

EPILEPSY & BEHAVIOR, 2008, 13 (02) :271-278

[8] Benign myoclonic epilepsy in infants:: Electroclinical features and long-term follow-up of 34 patients [J].

Auvin, S ;

Pandit, F ;

De Bellecize, J ;

Badinand, N ;

Isnard, H ;

Motte, J ;

Villeneuve, N ;

Lamblin, MD ;

Vallée, L .

EPILEPSIA, 2006, 47 (02) :387-393

[9] Add-on therapy with topiramate in progressive myoclonic epilepsy [J].

Aykutlu, E ;

Baykan, B ;

Gürses, C ;

Bebek, N ;

Büyükbabani, N ;

Gökyigit, A .

EPILEPSY & BEHAVIOR, 2005, 6 (02) :260-263

[10] PERSONALITY IN EPILEPSY - MULTIDIMENSIONAL STUDY OF PERSONALITY-TRAITS AD MODUM SJOBRING [J].

BECH, P ;

KJAERSGARDPEDERSEN, K ;

SIMONSEN, N ;

LUND, M .

ACTA NEUROLOGICA SCANDINAVICA, 1976, 54 (04) :348-358

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