Epidermolysis bullosa pruriginosa treated with dupilumab

被引：25

作者：

Zhou, Amanda G. ^{[1
]}

Little, Alicia J. ^{[2
]}

Antaya, Richard J. ^{[2
,3
]}

机构：

[1] Yale Univ, Sch Med, 333 Cedar St, New Haven, CT 06520 USA

[2] Yale Univ, Sch Med, Dept Dermatol, 333 Cedar St,POB 208059, New Haven, CT 06520 USA

[3] Yale Univ, Sch Med, Dept Pediat, New Haven, CT 06520 USA

来源：

PEDIATRIC DERMATOLOGY | 2021年 / 38卷 / 02期

关键词：

dupilumab; epidermolysis bullosa dystrophica; epidermolysis bullosa pruriginosa; pruritus; therapy— systemic;

D O I：

10.1111/pde.14493

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Epidermolysis bullosa pruriginosa (EBP) is a variant of dystrophic epidermolysis bullosa characterized by intense pruritus and prurigo nodularis-like lesions. While medical therapies for EBP exist, current treatments are not consistently effective, and symptoms often cause decreased quality of life. Here, we report two cases of EBP treated with dupilumab, which decreased symptoms of pruritus and improved skin findings. Both patients have been on dupilumab for over one year with sustained improvement and no adverse effects; although in one patient, increased dosing was required to attain optimal control of disease.

引用

页码：526 / 527

页数：2

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