Generation of reactive oxygen species by mitochondria in senescence-accelerated OXYS rats

被引：4
|
作者：
Men'shchikova, EB
Shabalina, IG
Zenkov, NK
Kolosova, NG
机构：
[1] Russian Acad Med Sci, Siberian Div, Res Ctr Clin & Expt Med, Moscow 109801, Russia
[2] Russian Acad Med Sci, Siberian Div, Inst Biochem, Moscow 109801, Russia
[3] Russian Acad Sci, Siberian Div, Inst Cytol & Genet, Novosibirsk, Russia
来源：
BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 2002年 / 133卷 / 02期
关键词：
OXYS rats; reactive oxygen species; mitochondria;
D O I：
10.1023/A:1015559124601
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Chemiluminescence assay showed that oxygen reduction and production of superoxide anion and hydrogen peroxide by liver mitochondria in OXYS rats highly sensitive to oxidative stress were less intensive than in Wistar rats. Experiments with cytochrome c oxidase inhibitors showed that decreased O-2(.) generation in mitochondria of OXYS rats is probably associated with changes in complex III of the electron transport chain.
引用
收藏
页码：175 / 177
页数：3
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