Screening for pulmonary arterial hypertension in systemic sclerosis: Now or never!

被引:8
作者
Brown, Zoe R. [1 ,2 ]
Nikpour, Mandana [1 ,2 ]
机构
[1] Univ Melbourne, Dept Med, Melbourne, Vic, Australia
[2] St Vincents Hosp, Clin Rheumatol, Melbourne, Vic, Australia
关键词
Scleroderma; systemic; pulmonary arterial hypertension; mass screening; diagnosis; DETECT ALGORITHM; FOLLOW-UP; ASSESSMENTS; PREVALENCE; MANAGEMENT; DIAGNOSIS;
D O I
10.5152/eurjrheum.2020.19114
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Systemic sclerosis (SSc), a chronic multisystem autoimmune disease characterized by fibrosis of the skin and internal organs and vasculopathy, has a high burden of mortality. One of the major contributors to mortality in patients with SSc is pulmonary arterial hypertension (PAH), which affects up to 10% of individuals and results in up to 15 years of life loss. Best practice recommendations are for asymptomatic patients with SSc and SSc-spectrum disorder to be screened annually for the early detection of SSc-PAH. Recently published data from large registries have shown improvements in the long-term outcomes in patients who are diagnosed with SSc-PAH because of systematic annual screening. This review will address the current clinical and research implications of the screening for the early detection of SSc-PAH.
引用
收藏
页码:S187 / S192
页数:6
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