CD44S-hyaluronan interactions protect cells resulting from EMT against anoikis

被引：34

作者：

Cieply, Benjamin ^{[1
]}

Koontz, Colton ^{[1
]}

Frisch, Steven M. ^{[1
]}

机构：

[1] W Virginia Univ, Mary Babb Randolph Canc Ctr, Morgantown, WV 26506 USA

来源：

MATRIX BIOLOGY | 2015年 / 48卷

关键词：

CD44; Hyaluronan; Anoikis; Apoptosis; Epithelial-mesenchymal transition; EPITHELIAL-MESENCHYMAL TRANSITION; HYALURONAN-BINDING; BREAST CANCERS; TUMOR-GROWTH; CD44; SUPPRESSION; ACTIVATION; EXPRESSION; REGULATOR;

D O I：

10.1016/j.matbio.2015.04.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The detachment of normal epithelial cells from matrix triggers an apoptotic response known as anoikis, during homeostatic turnover. Metastatic tumor cells evade anoikis, by mechanisms that are only partly characterized. In particular, the epithelial-mesenchymal transition (EMT) in a subset of invasive tumor cells confers anoikis-resistance. In some cases, EMT up-regulates the cancer stem cell marker CD44S and the enzyme hyaluronic acid synthase-2 (HAS2). CD44S is the major receptor for hyaluronan in the extracellular matrix. Herein, we demonstrate that CD44S, unlike the CD44E isoform expressed in normal epithelial cells, contributes to the protection against anoikis. This protection requires the interaction of CD44S with hyaluronan (HA). CD44S HA interaction is proposed to play an important role in tumor metastasis through enhanced cell survival under detached conditions. (C) 2015 Published by Elsevier B.V.

引用

页码：55 / 65

页数：11

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