Dendritic Cell-Derived Exosomes as Immunotherapies in the Fight against Cancer

被引：240
作者：
Pitt, Jonathan M. [1 ,2 ]
Charrier, Melinda [1 ,2 ]
Viaud, Sophie [1 ,2 ]
Andre, Fabrice [2 ,3 ,4 ]
Besse, Benjamin [2 ,5 ]
Chaput, Nathalie [1 ,2 ]
Zitvogel, Laurence [1 ,2 ,6 ]
机构：
[1] INSERM, Unit U1015, F-98405 Villejuif, France
[2] Univ Paris 06, Fac Med, F-94276 Le Kremlin Bicetre, France
[3] INSERM, Unit U981, F-98405 Villejuif, France
[4] Dept Med Oncol, F-98405 Villejuif, France
[5] Dept Canc Med, F-98405 Villejuif, France
[6] Ctr Clin Invest Biotherapies Canc 507, F-98405 Villejuif, France
来源：
JOURNAL OF IMMUNOLOGY | 2014年 / 193卷 / 03期
关键词：
PEPTIDE-BASED VACCINE; PROMOTE TUMOR-GROWTH; T-CELLS; ANTIGEN; MICROVESICLES; MECHANISM; ACTIVATION; INDUCTION; COMPLEXES; MICRORNAS;
D O I：
10.4049/jimmunol.1400703
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Exosomes are nanometric membrane vesicles of late endosomal origin released by most, if not all, cell types as a means of sophisticated intercellular communication. A multitude of studies showed how exosomes can mediate and regulate immune responses against tumors. Dendritic cell-derived exosomes (Dex) have received much attention as immunotherapeutic anticancer agents since the discovery that they harbor functional MHC-peptide complexes, in addition to various other immune-stimulating components, that together facilitate immune cell-dependent tumor rejection. The therapeutic potential of Dex has been substantiated with their development and clinical testing in the treatment of cancer. This review focuses on mechanisms by which Dex interact with and influence immune cells and describes how they can be engineered to promote their immunogenic capacity as novel and dynamic anticancer agents.
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收藏
页码：1006 / 1011
页数：6
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