Optical coherence tomography for thyroid pathology: 3D analysis of tissue microstructure

被引：4

作者：

Tampu, Iulian Emil ^{[1
]}

Maintz, Michaela ^{[1
]}

Koller, Daniela ^{[1
]}

Johansson, Kenth ^{[2
,3
]}

Gimm, Oliver ^{[4
,5
]}

Capitanio, Arrigo ^{[5
,6
]}

Eklund, Anders ^{[1
,7
,8
]}

Haj-Hosseini, Neda ^{[1
]}

机构：

[1] Linkoping Univ, Dept Biomed Engn, S-58185 Linkoping, Sweden

[2] Vastervik Hosp, Dept Surg, Vastervik, Sweden

[3] Orebro Univ Hosp, Orebro, Sweden

[4] Linkoping Univ Hosp, Dept Surg, S-58185 Linkoping, Sweden

[5] Linkoping Univ, Dept Biomed & Clin Sci, S-58185 Linkoping, Sweden

[6] Linkoping Univ, Dept Clin Pathol, S-58185 Linkoping, Sweden

[7] Linkoping Univ, Div Stat & Machine Learning, Dept Comp & Informat Sci, S-58183 Linkoping, Sweden

[8] Linkoping Univ, Ctr Med Image Sci & Visualizat, S-58185 Linkoping, Sweden

来源：

BIOMEDICAL OPTICS EXPRESS | 2020年 / 11卷 / 08期

关键词：

SEGMENTATION; SURGERY; GUIDANCE; SPECKLE; IMAGES;

D O I：

10.1364/BOE.394296

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

To investigate the potential of optical coherence tomography (OCT) to distinguish between normal and pathologic thyroid tissue, 3D OCT images were acquired on ex vivo thyroid samples from adult subjects (n =22) diagnosed with a variety of pathologies. The follicular structure was analyzed in terms of count, size, density and sphericity. Results showed that OCT images highly agreed with the corresponding histopatology and the calculated parameters were representative of the follicular structure variation. The analysis of OCT volumes provides quantitative information that could make automatic classification possible. Thus, OCT can be beneficial for intraoperative surgical guidance or in the pathology assessment routine. (C) 2020 Optical Society of America under the terms of the OSA Open Access Publishing Agreement

引用

页码：4130 / 4149

页数：20

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