Nanoengineering of a Biocompatible Organogel by Thermal Processing

被引：62

作者：

Li, Jing-Liang ^{[1
,2
]}

Wang, Rong-Yao ^{[1
,3
]}

Liu, Xiang-Yang ^{[1
]}

Pan, Hai-Hua ^{[1
]}

机构：

[1] Natl Univ Singapore, Dept Phys, Singapore 117542, Singapore

[2] Swinburne Univ Technol, Fac Engn & Ind Sci, Ctr Microphoton, Hawthorn, Vic 3122, Australia

[3] Beijing Inst Technol, Dept Appl Phys, Beijing 100081, Peoples R China

来源：

JOURNAL OF PHYSICAL CHEMISTRY B | 2009年 / 113卷 / 15期

关键词：

IN-VITRO RELEASE; 12-HYDROXYSTEARIC ACID; FIBER NETWORK; SUPRAMOLECULAR MATERIALS; FUNCTIONAL MATERIALS; CONTROLLED DELIVERY; ORGANIC LIQUIDS; CARBON-DIOXIDE; GEL; ARCHITECTURE;

D O I：

10.1021/jp811215t

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

The formation of most organogels requires the compatibility of both the gelator and solvent. It is very desirable if the theological properties of a gel can be manipulated to achieve the desired performance. In this paper, a novel organogel was developed and its theological properties and fiber network were engineered by controlling the thermal processing conditions. The gel was formed by the gelation of 12-hydroxystearic acid as a gelator in benzyl benzoate. It was observed that the degree of supercooling for gel formation has a significant effect on the theological properties and fiber network structure. By increasing supercooling, the elasticity of the gel was enhanced, and the correlation length of the fibers was shortened, leading to the formation of denser fiber networks. The good biocompatibility of both the gelator and solvent makes this gel a promising vehicle for a variety of bioapplications such as controlled transdermal drug release and in vivo tissue repair.

引用

页码：5011 / 5015

页数：5

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