The Impact of Caloric Restriction on the Epigenetic Signatures of Aging

被引：66
|
作者：
Gensous, Noemie [1 ]
Franceschi, Claudio [2 ,3 ]
Santoro, Aurelia [1 ]
Milazzo, Maddalena [1 ]
Garagnani, Paolo [1 ,4 ,5 ,6 ,7 ]
Bacalini, Maria Giulia [2 ]
机构：
[1] Univ Bologna, Dept Expt Diagnost & Specialty Med DIMES, I-40126 Bologna, Italy
[2] IRCCS Ist Sci Neurol Bologna, I-40139 Bologna, Italy
[3] Lobachevsky State Univ Nizhny Novgorod, Nizhnii Novgorod 603022, Russia
[4] St Orsola Malpighi Univ Hosp, Ctr Appl Biomed Res CRBA, I-40138 Bologna, Italy
[5] Huddinge Univ Hosp, Karolinska Inst, Dept Lab Med, Clin Chem, S-14186 Stockholm, Sweden
[6] Inst Mol Genet IGM CNR, Unit Bologna, I-40136 Bologna, Italy
[7] Rizzoli Orthoped Inst, Lab Musculoskeletal Cell Biol, I-40136 Bologna, Italy
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2019年 / 20卷 / 08期
关键词：
aging; nutrition; caloric restriction; epigenetic clocks; LIFE-SPAN EXTENSION; DNA METHYLATION AGE; GENE-EXPRESSION; BIOLOGICAL AGE; RHESUS-MONKEYS; MORTALITY; SURVIVAL; CLOCK; SIRT1; METAANALYSIS;
D O I：
10.3390/ijms20082022
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aging is characterized by an extensive remodeling of epigenetic patterns, which has been implicated in the physiopathology of age-related diseases. Nutrition plays a significant role in modulating the epigenome, and a growing amount of data indicate that dietary changes can modify the epigenetic marks associated with aging. In this review, we will assess the current advances in the relationship between caloric restriction, a proven anti-aging intervention, and epigenetic signatures of aging. We will specifically discuss the impact of caloric restriction on epigenetic regulation and how some of the favorable effects of caloric restriction on lifespan and healthspan could be mediated by epigenetic modifications.
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页数：14
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