Telomerase activation as a possible mechanism of action for psychopharmacological interventions

被引：43

作者：

Bersani, Francesco S. ^{[1
,2
]}

Lindqvist, Daniel ^{[1
,3
]}

Mellon, Synthia H. ^{[4
]}

Penninx, Brenda W. J. H. ^{[5
,6
]}

Verhoeven, Josine E. ^{[5
,6
]}

Revesz, Dora ^{[5
,6
]}

Reus, Victor I. ^{[1
]}

Wolkowitz, Owen M. ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[2] Univ Roma La Sapienza, Dept Neurol & Psychiat, I-00185 Rome, Italy

[3] Lund Univ, Dept Clin Sci, Sect Psychiat, Lund, Sweden

[4] Univ Calif San Francisco, Dept OB GYN & Reprod Sci, San Francisco, CA 94143 USA

[5] Vrije Univ Amsterdam Med Ctr, Dept Psychiat, Amsterdam, Netherlands

[6] Vrije Univ Amsterdam Med Ctr, EMGO Inst Hlth & Care Res, Amsterdam, Netherlands

来源：

DRUG DISCOVERY TODAY | 2015年 / 20卷 / 11期

关键词：

REVERSE-TRANSCRIPTASE; PSYCHIATRIC-DISORDERS; NEUROTROPHIC FACTOR; HIPPOCAMPAL VOLUME; BIPOLAR DISORDER; OXIDATIVE STRESS; LENGTH; SCHIZOPHRENIA; EXPRESSION; DEPRESSION;

D O I：

10.1016/j.drudis.2015.06.016

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Originally studied in relation to aging and cancer research, telomerase is now also investigated in relation to psychiatric disorders and treatments. Based on emerging clinical and preclinical data, we hypothesise that telomerase activation could represent a novel element mediating the mechanism of action of certain psychopharmacological interventions (e.g. antidepressants, lithium and antipsychotics). The modulation of intracellular Wnt/beta-catenin or PI3K/Akt signalling pathways, the interaction with BDNF and 5-HT, and the antioxidant properties could represent possible mechanisms by which the different types of psychiatric medications could modulate telomerase activity. The potential of telomerase in promoting cellular survival and/or function in the brain and in the periphery could, in turn, represent a neurobiological substrate through which the enzyme can mediate the therapeutic effect of such interventions.

引用

页码：1305 / 1309

页数：5

共 33 条

[1]

[Anonymous], 2011, DIALOGUES CLIN NEURO, V13, P25

[2] Impartial comparative analysis of measurement of leukocyte telomere length/DNA content by Southern blots and qPCR [J].

Aviv, Abraham ;

Hunt, Steven C. ;

Lin, Jue ;

Cao, Xiaojian ;

Kimura, Masayuki ;

Blackburn, Elizabeth .

NUCLEIC ACIDS RESEARCH, 2011, 39 (20)

[3] Association between telomere length in blood and mortality in people aged 60 years or older [J].

Cawthon, RM ;

Smith, KR ;

O'Brien, E ;

Sivatchenko, A ;

Kerber, RA .

LANCET, 2003, 361 (9355) :393-395

[4] Telomeres and telomerase [J].

Chan, SRWL ;

Blackburn, EH .

PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 2004, 359 (1441) :109-121

[5]

Duman RS, 2001, J PHARMACOL EXP THER, V299, P401

[6]

Fu WM, 2002, J NEUROSCI, V22, P10710

[7] Telomerase as a Growth-Promoting Factor [J].

Gorbunova, Vera ;

Seluanov, Andrei .

CELL CYCLE, 2003, 2 (06) :534-537

[8] Cycloastragenol Is a Potent Telomerase Activator in Neuronal Cells: Implications for Depression Management [J].

Ip, Fanny C. F. ;

Ng, Yu Pong ;

An, H. J. ;

Dai, Ying ;

Pang, Hai Hong ;

Hu, Yue Qing ;

Chin, Allison C. ;

Harley, Calvin B. ;

Wong, Yung Hou ;

Ip, Nancy Y. .

NEUROSIGNALS, 2014, 22 (01) :52-63

[9] Relationship Between Leukocyte Telomere Length, Telomerase Activity, and Hippocampal Volume in Early Aging [J].

Jacobs, Emily G. ;

Epel, Elissa S. ;

Lin, Jue ;

Blackburn, Elizabeth H. ;

Rasgon, Natalie L. .

JAMA NEUROLOGY, 2014, 71 (07) :921-923

[10] Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice [J].

Jaskelioff, Mariela ;

Muller, Florian L. ;

Paik, Ji-Hye ;

Thomas, Emily ;

Jiang, Shan ;

Adams, Andrew C. ;

Sahin, Ergun ;

Kost-Alimova, Maria ;

Protopopov, Alexei ;

Cadinanos, Juan ;

Horner, James W. ;

Maratos-Flier, Eleftheria ;

DePinho, Ronald A. .

NATURE, 2011, 469 (7328) :102-U1700

← 1 2 3 4 →