Association between VNTR polymorphism in promoter region of prodynorphin (PDYN) gene and heroin dependence

被引：19

作者：

Saify, Khyber ^{[1
]}

Saadat, Iraj ^{[1
,2
]}

Saadat, Mostafa ^{[1
,2
]}

机构：

[1] Shiraz Univ, Coll Sci, Dept Biol, Shiraz 71454, Iran

[2] Shiraz Univ, Inst Biotechnol, Shiraz 71454, Iran

来源：

PSYCHIATRY RESEARCH | 2014年 / 219卷 / 03期

关键词：

Heroin dependence; PDYN; VNTR;

D O I：

10.1016/j.psychres.2014.06.048

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Within the core promoter region of prodynorphin (PDYN), a 68-bp sequence was found to occur as a polymorphism element, either singular or as tandemly repeated two, three or four times. We report the sequence of a novel allele (5-repeats). Our study revealed the existence of an ancestral nucleotide (A) at 29th position of the VNTR in human. In total, 442 heroin addicts and 799 controls were included in this study. The present. findings revealed a male-limited association between VNTR polymorphism and heroin dependence risk. (C) 2014 Elsevier Ireland Ltd. All rights reserved.

引用

页码：690 / 692

页数：3

共 8 条

[1] Male limited association of the dopamine receptor D2 gene TaqI A polymorphism and alcohol dependence [J].

Limosin, F ;

Gorwood, P ;

Loze, JY ;

Dubertret, C ;

Gouya, L ;

Deybach, JC ;

Adès, J .

AMERICAN JOURNAL OF MEDICAL GENETICS, 2002, 112 (04) :343-346

[2] Glutathione S-transferase genetic polymorphisms (GSTM1, GSTT1 and GSTO2) in three Iranian populations [J].

Rafiee, Laleh ;

Saadat, Iraj ;

Saadat, Mostafa .

MOLECULAR BIOLOGY REPORTS, 2010, 37 (01) :155-158

[3] Ancient and recent positive selection transformed opioid cis-regulation in humans [J].

Rockman, MV ;

Hahn, MW ;

Soranzo, N ;

Zimprich, F ;

Goldstein, DB ;

Wray, GA .

PLOS BIOLOGY, 2005, 3 (12) :2208-2219

[4] Cell-specific effects of variants of the 68-base pair tandem repeat on prodynorphin gene promoter activity [J].

Rouault, Morgane ;

Nielsen, David A. ;

Ho, Ann ;

Kreek, Mary Jeanne ;

Yuferov, Vadim .

ADDICTION BIOLOGY, 2011, 16 (02) :334-346

[5] Polymorphism of XRCC1 (at codon 399) and susceptibility to breast cancer, a meta-analysis of the literatures [J].

Saadat, Mostafa ;

Ansari-Lari, Maryam .

BREAST CANCER RESEARCH AND TREATMENT, 2009, 115 (01) :137-144

[6] 30 years of dynorphins - New insights on their functions in neuropsychiatric diseases [J].

Schwarzer, Christoph .

PHARMACOLOGY & THERAPEUTICS, 2009, 123 (03) :353-370

[7] Association between heroin dependence and prodynorphin gene polymorphisms [J].

Wei, S. G. ;

Zhu, Y. S. ;

Lai, J. H. ;

Xue, H. X. ;

Chai, Z. Q. ;

Li, S. B. .

BRAIN RESEARCH BULLETIN, 2011, 85 (3-4) :238-242

[8] An allelic variation in the human prodynorphin gene promoter alters stimulus-induced expression [J].

Zimprich, A ;

Kraus, J ;

Wöltje, M ;

Mayer, P ;

Rauch, E ;

Höllt, V .

JOURNAL OF NEUROCHEMISTRY, 2000, 74 (02) :472-477

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