The Function of Astrocyte Mediated Extracellular Vesicles in Central Nervous System Diseases

被引：62
作者：
Gharbi, Tahereh [1 ]
Zhang, Zhijun [1 ]
Yang, Guo-Yuan [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Jiao Tong Univ Affiliated Peoples Hosp 6, Sch Biomed Engn, Shanghai, Peoples R China
来源：
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2020年 / 8卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
astrocyte; brain; extracellular vesicle; exosome; stem cell; CHEMOKINE RECEPTORS; EXOSOMES; BRAIN; MECHANISM; CANCER; CELLS; MICROVESICLES; BIOMARKERS; SECRETION; MICRORNAS;
D O I：
10.3389/fcell.2020.568889
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Astrocyte activation plays an important role during disease-induced inflammatory response in the brain. Exosomes in the brain could be released from bone marrow (BM)-derived stem cells, neuro stem cells (NSC), mesenchymal stem cells (MSC), etc. We summarized that exosomes release and transport signaling to the target cells, and then produce function. Furthermore, we discussed the pathological interactions between astrocytes and other brain cells, which are related to brain diseases such as stroke, Alzheimer's disease (AD), Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) disease, multiple sclerosis (MS), psychiatric, traumatic brain injury (TBI), etc. We provide up-to-date, comprehensive and valuable information on the involvement of exosomes in brain diseases, which is beneficial for basic researchers and clinical physicians.
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页数：15
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共 183 条
[1]   Exosomes in cancer: small vesicular transporters for cancer progression and metastasis, biomarkers in cancer therapeutics [J].
Abak, Atefe ;
Abhari, Alireza ;
Rahimzadeh, Sevda .
PEERJ, 2018, 6
[2]   Astrocyte-endothelial interactions at the blood-brain barrier [J].
Abbott, NJ ;
Rönnbäck, L ;
Hansson, E .
NATURE REVIEWS NEUROSCIENCE, 2006, 7 (01) :41-53
[3]   The diversity and disparity of the glial scar [J].
Adams, Katrina L. ;
Gallo, Vittorio .
NATURE NEUROSCIENCE, 2018, 21 (01) :9-15
[4]   Astrocyte-neuron metabolic relationships: for better and for worse [J].
Allaman, Igor ;
Belanger, Mireille ;
Magistretti, Pierre J. .
TRENDS IN NEUROSCIENCES, 2011, 34 (02) :76-87
[5]   Exosomal secretion of a psychosis-altered miRNA that regulates glutamate receptor expression is affected by antipsychotics [J].
Amoah, Stephen K. ;
Rodriguez, Brian A. ;
Logothetis, Constantine N. ;
Chander, Praveen ;
Sellgren, Carl M. ;
Weick, Jason P. ;
Sheridan, Steven D. ;
Jantzie, Lauren L. ;
Webster, Maree J. ;
Mellios, Nikolaos .
NEUROPSYCHOPHARMACOLOGY, 2020, 45 (04) :656-665
[6]   Heterogeneity of reactive astrocytes [J].
Anderson, Mark A. ;
Ao, Yan ;
Sofroniew, Michael V. .
NEUROSCIENCE LETTERS, 2014, 565 :23-29
[7]   Glial and neuronal control of brain blood flow [J].
Attwell, David ;
Buchan, Alastair M. ;
Charpak, Serge ;
Lauritzen, Martin ;
MacVicar, Brian A. ;
Newman, Eric A. .
NATURE, 2010, 468 (7321) :232-243
[8]   Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species [J].
Baglio, Serena Rubina ;
Rooijers, Koos ;
Koppers-Lalic, Danijela ;
Verweij, Frederik J. ;
Lanzon, M. Perez ;
Zini, Nicoletta ;
Naaijkens, Benno ;
Perut, Francesca ;
Niessen, Hans W. M. ;
Baldini, Nicola ;
Pegtel, D. Michiel .
STEM CELL RESEARCH & THERAPY, 2015, 6
[9]   Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy for Stroke: Challenges and Progress [J].
Bang, Oh Young ;
Kim, Eun Hee .
FRONTIERS IN NEUROLOGY, 2019, 10
[10]   Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes IMPLICATIONS FOR DISEASE SPREADING AND MOTOR NEURON PATHOLOGY IN AMYOTROPHIC LATERAL SCLEROSIS [J].
Basso, Manuela ;
Pozzi, Silvia ;
Tortarolo, Massimo ;
Fiordaliso, Fabio ;
Bisighini, Cinzia ;
Pasetto, Laura ;
Spaltro, Gabriella ;
Lidonnici, Dario ;
Gensano, Francesco ;
Battaglia, Elisa ;
Bendotti, Caterina ;
Bonetto, Valentina .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (22) :15699-15711
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