Multiple Myeloma: Diagnosis and Treatment

被引：348

作者：

Rajkumar, S. Vincent ^{[1
]}

Kumar, Shaji ^{[1
]}

机构：

[1] Mayo Clin, Div Hematol, Rochester, MN 55905 USA

来源：

MAYO CLINIC PROCEEDINGS | 2016年 / 91卷 / 01期

关键词：

STEM-CELL TRANSPLANTATION; LENALIDOMIDE PLUS DEXAMETHASONE; INTERNATIONAL STAGING SYSTEM; LOW-DOSE DEXAMETHASONE; UNDETERMINED SIGNIFICANCE MGUS; UPDATED MAYO STRATIFICATION; BONE-MARROW-TRANSPLANTATION; RANDOMIZED PHASE-III; MONOCLONAL GAMMOPATHY; DOUBLE-BLIND;

D O I：

10.1016/j.mayocp.2015.11.007

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The diagnosis and treatment of multiple myeloma has changed dramatically in the past decade. The disease definition has been updated to include highly specific biomarkers in addition to established markers of end-organ damage. The staging system has been revised to combine both measures of tumor burden and disease biology. Advances in therapy have resulted in a marked improvement in overall survival. New drugs introduced in the past few years include carfilzomib, pomalidomide, panobinostat, ixazomib, elotuzumab, and daratumumab. In this review, we outline the current approach to the diagnosis, prognosis, and management of multiple myeloma. (C) 2016 Mayo Foundation for Medical Education and Research

引用

页码：101 / 119

页数：19

共 133 条

[1] Single versus double autologous stem-cell transplantation for multiple myeloma [J].

Attal, M ;

Harousseau, JL ;

Facon, T ;

Guilhot, F ;

Doyen, C ;

Fuzibet, JG ;

Monconduit, M ;

Hulin, C ;

Caillot, D ;

Bouabdallah, R ;

Voillat, L ;

Sotto, JJ ;

Grosbois, B ;

Bataille, R .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (26) :2495-2502

[2] A prospective, randomized trial of autologous bone marrow transplantation and chemotherapy in multiple myeloma [J].

Attal, M ;

Harousseau, JL ;

Stoppa, AM ;

Sotto, JJ ;

Fuzibet, JG ;

Rossi, JF ;

Casassus, P ;

Maisonneuve, H ;

Facon, T ;

Ifrah, N ;

Payen, C ;

Bataille, R .

NEW ENGLAND JOURNAL OF MEDICINE, 1996, 335 (02) :91-97

[3]

Attal M, ASH ANN M 2015 AM SO

[4] Maintenance, therapy with thalidomide improves survival in patients with multiple myeloma [J].

Attal, Michel ;

Harousseau, Jean-Luc ;

Leyvraz, Serge ;

Doyen, Chantal ;

Hulin, Cyrille ;

Benboubker, Lofti ;

Agha, Ibrahim Yakoub ;

Bourhis, Jean-Henri ;

Garderet, Laurent ;

Pegourie, Brigitte ;

Dumontet, Charles ;

Renaud, Marc ;

Voillat, Laurent ;

Berthou, Christian ;

Marit, Gerald ;

Monconduit, Mathieu ;

Caillot, Denis ;

Grobois, Bernard ;

Avet-Loiseau, Herve ;

Moreau, Philippe ;

Facon, Thierry .

BLOOD, 2006, 108 (10) :3289-3294

[5] Lenalidomide Maintenance after Stem-Cell Transplantation for Multiple Myeloma [J].

Attal, Michel ;

Lauwers-Cances, Valerie ;

Marit, Gerald ;

Caillot, Denis ;

Moreau, Philippe ;

Facon, Thierry ;

Stoppa, Anne Marie ;

Hulin, Cyrille ;

Benboubker, Lofti ;

Garderet, Laurent ;

Decaux, Olivier ;

Leyvraz, Serge ;

Vekemans, Marie-Christiane ;

Voillat, Laurent ;

Michallet, Mauricette ;

Pegourie, Brigitte ;

Dumontet, Charles ;

Roussel, Murielle ;

Leleu, Xavier ;

Mathiot, Claire ;

Payen, Catherine ;

Avet-Loiseau, Herve ;

Harousseau, Jean-Luc .

NEW ENGLAND JOURNAL OF MEDICINE, 2012, 366 (19) :1782-1791

[6] Superiority of tandem autologous transplantation over standard therapy for previously untreated multiple myeloma [J].

Barlogie, B ;

Jagannath, S ;

Vesole, DH ;

Naucke, S ;

Cheson, B ;

Mattox, S ;

Bracy, D ;

Salmon, S ;

Jacobson, J ;

Crowley, J ;

Tricot, G .

BLOOD, 1997, 89 (03) :789-793

[7] Total therapy with tandem transplants for newly diagnosed multiple myeloma [J].

Barlogie, B ;

Jagannath, S ;

Desikan, KR ;

Mattox, S ;

Vesole, D ;

Siegel, D ;

Tricot, G ;

Munshi, N ;

Fassas, A ;

Singhal, S ;

Mehta, J ;

Anaissie, E ;

Dhodapkar, D ;

Naucke, S ;

Cromer, J ;

Sawyer, J ;

Epstein, J ;

Spoon, D ;

Ayers, D ;

Cheson, B ;

Crowley, J .

BLOOD, 1999, 93 (01) :55-65

[8]

Barlogie B, 2003, BLOOD, V102, p42a

[9] Incorporating bortezomib into upfront treatment for multiple myeloma: early results of total therapy 3 [J].

Barlogie, Bart ;

Anaissie, Elias ;

van Rhee, Frits ;

Haessler, Jeffrey ;

Hollmig, Klaus ;

Pineda-Roman, Mauricio ;

Cottler-Fox, Michele ;

Mohiuddin, Abid ;

Alsayed, Yazan ;

Tricot, Guido ;

Bolejack, Vanessa ;

Zangari, Maurizio ;

Epstein, Joshua ;

Petty, Nathan ;

Steward, Douglas ;

Jenkins, Bonnie ;

Gurley, Jennifer ;

Sullivan, Ellen ;

Crowley, John ;

Shaughnessy, John D. Jr .

BRITISH JOURNAL OF HAEMATOLOGY, 2007, 138 (02) :176-185

[10] Lenalidomide and Dexamethasone in Transplant-Ineligible Patients with Myeloma [J].

Benboubker, Lotfi ;

Dimopoulos, Meletios A. ;

Dispenzieri, Angela ;

Catalano, John ;

Belch, Andrew R. ;

Cavo, Michele ;

Pinto, Antonello ;

Weisel, Katja ;

Ludwig, Heinz ;

Bahlis, Nizar ;

Banos, Anne ;

Tiab, Mourad ;

Delforge, Michel ;

Cavenagh, Jamie ;

Geraldes, Catarina ;

Lee, Je-Jung ;

Chen, Christine ;

Oriol, Albert ;

de la Rubia, Javier ;

Qiu, Lugui ;

White, Darrell J. ;

Binder, Daniel ;

Anderson, Kenneth ;

Fermand, Jean-Paul ;

Moreau, Philippe ;

Attal, Michel ;

Knight, Robert ;

Chen, Guang ;

Van Oostendorp, Jason ;

Jacques, Christian ;

Ervin-Haynes, Annette ;

Avet-Loiseau, Herve ;

Hulin, Cyrille ;

Facon, Thierry .

NEW ENGLAND JOURNAL OF MEDICINE, 2014, 371 (10) :906-917

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