Autophagy-related MicroRNAs in chronic lung diseases and lung cancer

被引：52

作者：

Rezaei, Samaneh ^{[1
]}

Mahjoubin-Tehran, Maryam ^{[1
]}

Aghaee-Bakhtiari, Seyed Hamid ^{[1
,2
]}

Jalili, Amin ^{[1
]}

Movahedpour, Ahmad ^{[3
]}

Khan, Haroon ^{[4
]}

Moghoofei, Mohsen ^{[5
]}

Shojaei, Zahra ^{[6
]}

Hamblin, Michael R. ^{[7
,8
]}

Mirzaei, Hamed ^{[9
]}

机构：

[1] Mashhad Univ Med Sci, Fac Med, Dept Med Biotechnol, Mashhad, Razavi Khorasan, Iran

[2] Mashhad Univ Med Sci, Bioinformat Res Grp, Mashhad, Razavi Khorasan, Iran

[3] Shiraz Univ Med Sci Shiraz, Sch Adv Med Sci & Technol, Dept Med Biotechnol, Shiraz, Iran

[4] Abdul Wali Khan Univ, Dept Pharm, Mardan 23200, Iran

[5] Kermanshah Univ Med Sci, Fac Med, Dept Microbiol, Kermanshah, Iran

[6] Shahid Beheshti Univ Med Sci, Sch Med, Tehran, Iran

[7] Harvard Med Sch, Wellman Ctr Photomed, Massachusetts Gen Hosp, 40 Blossom St, Boston, MA 02114 USA

[8] Univ Johannesburg, Fac Hlth Sci, Laser Res Ctr, ZA-2028 Doornfontein, South Africa

[9] Kashan Univ Med Sci, Res Ctr Biochem & Nutr Metab Dis, Inst Basic Sci, Kashan, Iran

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2020年 / 153卷

关键词：

Autophagy; microRNAs; Chronic obstructive lung disease; Cystic fibrosis; Idiopathic pulmonary fibrosis; Lung cancer; TRANSMEMBRANE CONDUCTANCE REGULATOR; OBSTRUCTIVE PULMONARY-DISEASE; GENOME-WIDE ASSOCIATION; AIRWAY EPITHELIAL-CELLS; CYSTIC-FIBROSIS; DOWN-REGULATION; TUMOR-GROWTH; HEPATOCELLULAR-CARCINOMA; CIGARETTE-SMOKE; BURKHOLDERIA-CENOCEPACIA;

D O I：

10.1016/j.critrevonc.2020.103063

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Chronic lung disease has become a leading cause of death in recent years. Despite several attempts to discover and develop new therapeutic approaches, patients often suffer a poor quality of life, and are faced with an increased risk of developing lung cancer. Lung cancer often occurs as an end-stage after years of chronic lung disease. An increased understanding of the pathophysiology of chronic lung disease may be obtained from studying the role of autophagy in its initiation and progression. MicroRNAs (miRNAs) play a critical role in the modulation of autophagy, and their deregulation could be associated with the initiation and progression of several chronic lung diseases. Herein, we documented that up/down regulation of miRNAs can activate or inhibit autophagy in chronic lung diseases including lung cancer. Therefore, theses miRNAs could be a promising therapeutic tool for lung cancer specially in drug-resistance lung cancer cells.

引用

页数：21

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