Mapping genes for complex traits in domestic animals and their use in breeding programmes

被引：742

作者：

Goddard, Michael E. ^{[1
,2
]}

Hayes, Ben J. ^{[2
]}

机构：

[1] Univ Melbourne, Dept Agr & Food Syst, Parkville, Vic 3010, Australia

[2] Dept Primary Ind, Biosci Res Div, Bundoora, Vic 3083, Australia

来源：

NATURE REVIEWS GENETICS | 2009年 / 10卷 / 06期

关键词：

EFFECTIVE POPULATION-SIZE; LINKAGE DISEQUILIBRIUM; DAIRY-CATTLE; FOOD CONVERSION; HOLSTEIN CATTLE; MYOSTATIN GENE; GENOME SCAN; DGAT1; GENE; LOCI; MUTATION;

D O I：

10.1038/nrg2575

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Genome-wide panels of SNPs have recently been used in domestic animal species to map and identify genes for many traits and to select genetically desirable livestock. This has led to the discovery of the causal genes and mutations for several single-gene traits but not for complex traits. However, the genetic merit of animals can still be estimated by genomic selection, which uses genome-wide SNP panels as markers and statistical methods that capture the effects of large numbers of SNPs simultaneously. This approach is expected to double the rate of genetic improvement per year in many livestock systems.

引用

页码：381 / 391

页数：11

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