Viral evolutionary changes during tenofovir treatment in a chronic hepatitis B patient with sequential nucleos(t)ide therapy

被引：20

作者：

Lee, Hyun Woong ^{[1
]}

Chang, Hye Young ^{[1
]}

Yang, Suh Yoon ^{[1
]}

Kim, Hyung Joon ^{[1
]}

机构：

[1] Chung Ang Univ, Coll Med, Dept Internal Med, Seoul 156755, South Korea

来源：

JOURNAL OF CLINICAL VIROLOGY | 2014年 / 60卷 / 03期

关键词：

Tenofovir; Chronic hepatitis B; Resistance; Mutation; SELECTION; FAILURE;

D O I：

10.1016/j.jcv.2014.03.018

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A 54-year-old man diagnosed with HBeAg-positive chronic hepatitis B (CHB) was treated with entecavir (ETV) 1 mg/day following an initial unsuccessful lamivudine (LAM) treatment (rtL180M, rtM204V/I). Subsequently, virological breakthrough with ETV mutation (rtT184A/L) developed. The LAM and adefovir combination therapy was followed by virological breakthrough. The therapy had been switched to TDF monotherapy. However, this patient experienced virological breakthrough under TDF with a HBV strain bearing rtL80M, rtL180M, rtM204V/I, rtA200V, rtF221Y, rt5223A, rtT184A/L, rtR153Q, and rtV191I combined mutations without rtA194T mutation. TDF resistance may emerge due to multi-site polymerase mutations rather than single-site polymerase mutation. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：313 / 316

页数：4

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