How gene colocalization can be optimized by tuning the diffusion constant of transcription factors

被引：13

作者：

Benichou, O. ^{[1
]}

Loverdo, C. ^{[1
]}

Voituriez, R. ^{[1
]}

机构：

[1] Univ Paris 06, Lab Phys Theor & Mat Condensee, UMR 7600, F-75255 Paris, France

来源：

EPL | 2008年 / 84卷 / 03期

关键词：

D O I：

10.1209/0295-5075/84/38003

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

We introduce an analytical model which shows quantitatively that gene colocalization significantly accelerates the association of transcriptions factors (TFs) with their target site on DNA. This model takes into account the influence of conformational fluctuations of TFs on reactivity, and shows that the benefit due to colocalization, highlighted by Kolesov et al. (Proc. Natl. Acad. Sci. U. S. A., 104 (2007) 13948), can be further optimized by tuning the diffusion coefficient of TFs. This diffusion optimized colocalization mechanism is robust and compatible with available experimental data, and could help understanding the observed gene transcription efficiency. Copyright (C) EPLA, 2008

引用

页数：3

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