Metalloantibiotics: synthesis and antibacterial activity of cefepime metal complexes

被引：16

作者：

Anacona, J. R. ^{[1
]}

Rodriguez, Heidy ^{[1
]}

机构：

[1] Univ Oriente, Dept Quim, Cumana, Venezuela

来源：

JOURNAL OF COORDINATION CHEMISTRY | 2009年 / 62卷 / 13期

关键词：

Cefepime metal complexes; Antibacterial activity; Transition metal complexes; PHARMACOKINETIC PROPERTIES; CEPHALOSPORINS; INHIBITION;

D O I：

10.1080/00958970902769815

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Cefepime interacts with transition metal(II) ions to give [M(cefepime)Cl2] complexes (M = Mn(II), Co(II), Ni(II), Cu(II), and Zn(II)) which were characterized by physicochemical and spectroscopic methods. The complexes are insoluble in water and common organic solvents, and probably have polymeric structures. The spectra indicated that the ligand is a multidentate chelating agent. The complexes have been screened for antibacterial activity against several bacteria and showed activity less than that of free cefepime.

引用

页码：2212 / 2219

页数：8

共 37 条

[1] Metalloantibiotics: synthesis and antibacterial activity of ceftazidime metal complexes [J].