A general theory of far-field optical microscopy image formation and resolution limit using double-sided Feynman diagrams

被引:7
作者
Fukutake, Naoki [1 ]
机构
[1] Nikon Inc, Sakae Ku, 471 Nagaodai Cho, Yokohama, Kanagawa 2448533, Japan
关键词
PHASE-CONTRAST;
D O I
10.1038/s41598-020-73584-1
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Optical resolution of far-field optical microscopy is limited by the diffraction of light, while diverse light-matter interactions are used to push the limit. The image resolution limit depends on the type of optical microscopy; however, the current theoretical frameworks provide oversimplified pictures of image formation and resolution that only address individual types of microscopy and light-matter interactions. To compare the fundamental optical resolutions of all types of microscopy and to codify a unified image-formation theory, a new method that describes the influence of light-matter interactions on the resolution limit is required. Here, we develop an intuitive technique using double-sided Feynman diagrams that depict light-matter interactions to provide a bird's-eye view of microscopy classification. This diagrammatic methodology also allows for the optical resolution calculation of all types of microscopy. We show a guidepost for understanding the potential resolution and limitation of all optical microscopy. This principle opens the door to study unexplored theoretical questions and lead to new applications.
引用
收藏
页数:12
相关论文
共 36 条
[1]  
Abbe E., 1873, Arch. Mikrosk. Anat, V9, P413, DOI DOI 10.1007/BF02956173
[2]  
[Anonymous], 1974, Principles of Optics
[3]  
[Anonymous], 1914, COLLOIDS ULTRAMICROS
[4]   Nonlinear scanning laser microscopy by third harmonic generation [J].
Barad, Y ;
Eisenberg, H ;
Horowitz, M ;
Silberberg, Y .
APPLIED PHYSICS LETTERS, 1997, 70 (08) :922-924
[5]   Time-, frequency-, and wavevector-resolved x-ray diffraction from single molecules [J].
Bennett, Kochise ;
Biggs, Jason D. ;
Zhang, Yu ;
Dorfman, Konstantin E. ;
Mukamel, Shaul .
JOURNAL OF CHEMICAL PHYSICS, 2014, 140 (20)
[6]   Imaging intracellular fluorescent proteins at nanometer resolution [J].
Betzig, Eric ;
Patterson, George H. ;
Sougrat, Rachid ;
Lindwasser, O. Wolf ;
Olenych, Scott ;
Bonifacino, Juan S. ;
Davidson, Michael W. ;
Lippincott-Schwartz, Jennifer ;
Hess, Harald F. .
SCIENCE, 2006, 313 (5793) :1642-1645
[7]  
Boyd RW, 2008, NONLINEAR OPTICS, 3RD EDITION, P1
[9]  
Çapoglu IR, 2009, OPT LETT, V34, P2679, DOI 10.1364/OL.34.002679
[10]   2-PHOTON LASER SCANNING FLUORESCENCE MICROSCOPY [J].
DENK, W ;
STRICKLER, JH ;
WEBB, WW .
SCIENCE, 1990, 248 (4951) :73-76