Manipulating macrophage polarization and function using classical HDAC inhibitors: Implications for autoimmunity and inflammation

被引：43

作者：

Mohammadi, Asadollah ^{[1
]}

Sharifi, Atefeh ^{[2
,3
]}

Pourpaknia, Reza ^{[4
]}

Mohammadian, Saeed ^{[5
]}

Sahebkar, Amirhossein ^{[6
,7
,8
]}

机构：

[1] Kurdistan Univ Med Sci, Fac Med, Cellular & Mol Res Ctr, Sanandaj, Iran

[2] Ahvaz Jundishapur Univ Med Sci, Sch Pharm, Ahvaz, Iran

[3] Ahvaz Jundishapur Univ Med Sci, Cellular & Mol Res Ctr, Ahvaz, Iran

[4] Zanjan Univ Med Sci, Sch Med, Dept Med Genet, Zanjan, Iran

[5] Mashhad Univ Med Sci, Fac Med, BuAli Res Inst, Student Res Comm,Immunol Res Ctr, Mashhad, Iran

[6] Mashhad Univ Med Sci, Pharmaceut Technol Inst, Biotechnol Res Ctr, Mashhad, Iran

[7] Mashhad Univ Med Sci, Neurogen Inflammat Res Ctr, Mashhad, Iran

[8] Mashhad Univ Med Sci, Sch Pharm, Mashhad, Iran

来源：

CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY | 2018年 / 128卷

关键词：

Histone deacetylase inhibitor; Macrophage polarization; Autoimmunity; Inflammation; HISTONE DEACETYLASE INHIBITORS; SUBEROYLANILIDE HYDROXAMIC ACID; NF-KAPPA-B; ANTIGEN-PRESENTING CELLS; MONOCYTE CHEMOATTRACTANT PROTEIN-1; PROINFLAMMATORY GENE-EXPRESSION; SMALL-MOLECULE INHIBITORS; VERSUS-HOST-DISEASE; CYTOKINES IN-VITRO; CHAIN FATTY-ACIDS;

D O I：

10.1016/j.critrevonc.2018.05.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Macrophages are important player in defense against invading pathogens and their dysfunction is linked to most of inflammatory and autoimmune diseases. Inflammation is a normal and physiological response of the immune system against harmful stimuli such as infection and injury. However, when allowed to continue unchecked, under certain conditions it turns into autoimmune or inflammatory diseases, neurodegeneration, and carcinogenesis. Currently, several safe and effective anti-inflammatory drugs are available with many more drugs in the development pipeline, among which are histone deacetylase inhibitors. In this review we discuss how post translational modifications of histones influence the innate and adaptive immunity through macrophage survival, proliferation, polarization and functional responses. We also discuss how emerging classes of pharmacological agents which developed for use as anti-cancer agents, have been applied as anti-inflammatory drugs to treat macrophage-mediated inflammatory and autoimmune diseases.

引用

页码：1 / 18

页数：18

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