Sentinel lymph node biopsy to stage patients with cutaneous melanoma at the National Cancer Institute of Naples.: Results from 240 sentinel node biopsies

被引:8
作者
Caracò, C [1 ]
Chiofalo, MG [1 ]
Niro, J [1 ]
Ascierto, PA [1 ]
Botti, G [1 ]
Lastoria, S [1 ]
Mozzillo, N [1 ]
机构
[1] Natl Canc Inst, Surg Div B, Naples, Italy
关键词
cutaneous melanoma; lymphadenectomy; sentinel node biopsy;
D O I
10.1177/030089160208800324
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Aims and background: The presence of lymph node metastases in patients with cutaneous melanoma represents the basis for correct therapy planning and is the most powerful prognostic factor to evaluate overall survival at diagnosis. Methods and study design: Since 1992, when Dr Morton published his first experience, the sentinel lymph node (SLN) biopsy technique seems to have resolved this matter by correctly staging patients. We analyzed our data from 240 SLN biopsies performed in the last five years at the National Cancer Institute of Naples, evaluating the total identification rate and the nodal recurrence rate, and compared them with the preliminary data of the MSLT (melanoma sentinel lymph node trial). Results: Of all SLNs evaluated 18.5% were micrometastatic and 14% were identified by immunohistochemical staining. Forty-one patients had metastatic SLNs and nodal dissection of the positive basins revealed no other tumor-positive lymph nodes in more than 80% of them. All patients with a Breslow thickness of less than 2 mm had micrometastases only in the SLN, while with increasing thickness two, three or more positive nodes were found. Among SLN-negative patients nine (4%) developed lymph node recurrence in the previously treated basin and were therefore considered as false negative SLN biopsies. Conclusions: The prognostic value of SLN biopsy needs to be confirmed by the final results of the MSLT evaluating the therapeutic use of this procedure in patients with a Breslow thickness of less than 2 mm and its possible impact on the course of the disease.
引用
收藏
页码:S12 / S13
页数:2
相关论文
共 12 条
  • [1] Long-term results of a multi-institutional randomized trial comparing prognostic factors and surgical results for intermediate thickness melanomas (1.0 to 4.0 mm)
    Balch, CM
    Soong, SJ
    Ross, MI
    Urist, MM
    Karakousis, CP
    Temple, WJ
    Mihm, MC
    Barnhill, RL
    Jewell, WR
    Wanebo, HJ
    Harrison, R
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2000, 7 (02) : 87 - 97
  • [2] Efficacy of an elective regional lymph node dissection of 1 to 4 mm thick melanomas for patients 60 years of age and younger
    Balch, CM
    Soong, SJ
    Bartolucci, AA
    Urist, MM
    Karakousis, CP
    Smith, TJ
    Temple, WJ
    Ross, MI
    Jewell, WR
    Mihm, MC
    Barnhill, RL
    Wanebo, HJ
    [J]. ANNALS OF SURGERY, 1996, 224 (03) : 255 - 263
  • [3] Incidence of sentinel node metastasis in patients with thin primary melanoma (≤1 mm) with vertical growth phase
    Bedrosian, I
    Faries, MB
    Guerry, D
    Elenitsas, R
    Schuchter, L
    Mick, R
    Spitz, FR
    Bucky, LP
    Alavi, A
    Elder, DE
    Fraker, DL
    Czerniecki, BJ
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2000, 7 (04) : 262 - 267
  • [4] CARACO C, 1997, J EXP CLIN CANC RES, V16, P244
  • [5] Immediate or delayed dissection of regional nodes in patients with melanoma of the trunk: a randomised trial
    Cascinelli, N
    Morabito, A
    Santinami, M
    MacKie, RM
    Belli, F
    [J]. LANCET, 1998, 351 (9105) : 793 - 796
  • [6] Sentinel lymph node biopsy in the management of patients with primary cutaneous melanoma: Review of a large single-institutional experience with an emphasis on recurrence
    Clary, BM
    Brady, MS
    Lewis, JJ
    Coit, DG
    [J]. ANNALS OF SURGERY, 2001, 233 (02) : 250 - 258
  • [7] Role for lymphatic mapping and sentinel lymph node biopsy in patients with thick (≥4 mm) primary melanoma
    Gershenwald, JE
    Mansfield, PF
    Lee, JE
    Ross, MI
    [J]. ANNALS OF SURGICAL ONCOLOGY, 2000, 7 (02) : 160 - 165
  • [8] Validation of the accuracy of intraoperative lymphatic mapping and sentinel lymphadenectomy for early-stage melanoma - A multicenter trial
    Morton, DL
    Thompson, JF
    Essner, R
    Elashoff, R
    Stern, SL
    Nieweg, OE
    Roses, DF
    Karakousis, CP
    Mozzillo, N
    Reintgen, D
    Wang, HJ
    Glass, EC
    Cochran, AJ
    [J]. ANNALS OF SURGERY, 1999, 230 (04) : 453 - 463
  • [9] MORTON DL, 1992, ARCH SURG-CHICAGO, V127, P392
  • [10] MOZZILLO N, 1999, ATT 101 C NAZ SIC, P158