Hypothalamic melanocortin system regulates sympathetic nerve activity in brown adipose tissue

被引：80

作者：

Yasuda, T ^{[1
]}

Masaki, T ^{[1
]}

Kakuma, T ^{[1
]}

Yoshimatsu, H ^{[1
]}

机构：

[1] Oita Univ, Dept Internal Med 1, Fac Med, Oita 8795593, Japan

来源：

EXPERIMENTAL BIOLOGY AND MEDICINE | 2004年 / 229卷 / 03期

关键词：

melanocortin; 4; receptor; agouti-related protein; alpha-melanocyte-stimulating hormone; brown adipose tissue; sympathetic nerve activity;

D O I：

10.1177/153537020422900303

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

To clarity the neuronal mechanism of the hypothalamic melanocortin system in regulating energy metabolism, we investigated the effects of centrally administered alpha-melanocyte-stimulating hormone (alpha-MSH) and agouti-related protein (AGRP), an agonist and an antagonist for the melanocortin 4 receptor (MC4-R), respectively, on the activity of sympathetic nerves innervating brown adipose tissue (BAT) and on BAT temperature. A bolus infusion of a-MSH (1 nmol) into the third cerebral ventricle (i3vt) significantly increased sympathetic nerve activity and elevated BAT temperature (P < 0.05). The i3vt infusion of AGRP (1 nmol) gradually suppressed BAT sympathetic nerve activity and was accompanied by a significant reduction in BAT temperature (P < 0.05). In conclusion, the hypothalamic melanocortin system may regulate peripheral energy expenditure, as well as thermogenesis, through its influence on BAT sympathetic nerve activity.

引用

页码：235 / 239

页数：5

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