Mechanisms of action of intravenous immunoglobulin in the treatment of immune thrombocytopenia

被引：43
作者：
Crow, Andrew R.
Song, Seng
Siragam, Vinayakumar
Lazarus, Alan H.
机构：
[1] Canadian Blood Serv, Toronto, ON, Canada
[2] Univ Toronto, Dept Lab Med, Toronto, ON, Canada
[3] Univ Toronto, Dep St Michaels Hosp Med, Toronto, ON, Canada
[4] Univ Toronto, Dep St Michaels Hosp Lab Med & Pathobiol, Toronto, ON, Canada
[5] Toronto Platelet Immunobiol Grp, Toronto, ON, Canada
来源：
PEDIATRIC BLOOD & CANCER | 2006年 / 47卷 / 05期
关键词：
immune complex; intravenous immunoglobulin; ITP;
D O I：
10.1002/pbc.20980
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Intravenous immunoglobulin (IVIG) is currently used to treat a multitude of autoimmune disorders including immune thrombocytopenic purpura (ITP), yet the mechanism of action of IVIG remains unresolved. Using a murine model of ITP in which IVIG functions therapeutically, our laboratory has addressed such theories as blockade/inhibition of the mononuclear phagocytic system, cytokine regulation, and neutralization of pathogenic autoantibodies mediated by anti-idiotypic antibodies, and these findings will be discussed herein. We have also demonstrated that soluble immune complexes can completely recapitulate the therapeutic effects of IVIG in ITP, and recent work from us has identified activating Fc gamma receptors on CD] 1 c(+) dendritic cells as the relevant molecular target of IVIG in the acute resolution of murine immune thrombocytopenia. This and other work to devise antibody-based IVIG alternative therapies will also be addressed. Pediatr Blood Cancer 2006;47:710-713. (c) 2006 Wiley-Liss, Inc.
引用
收藏
页码：710 / 713
页数：4
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