Management of right ventricular dysfunction in the perioperative setting

被引:1
作者
Zarbock, Alexander [1 ]
Van Aken, Hugo [1 ]
Schmidt, Christoph [1 ]
机构
[1] Univ Munster, Dept Anesthesiol Intens Care & Pain Med, D-48149 Munster, Germany
关键词
management; perioperative; right ventricular failure; right ventricular function; INHALED NITRIC-OXIDE; RIGHT-HEART-FAILURE; PULMONARY-HYPERTENSION; CARDIOVASCULAR-DISEASE; EMBOLISM; PATHOPHYSIOLOGY; LEVOSIMENDAN; PROSTACYCLIN; DOBUTAMINE; INHIBITION;
D O I
10.1097/ACO.0000000000000092
中图分类号
R614 [麻醉学];
学科分类号
100217 ;
摘要
Purpose of review This review summarizes the approach to and recent developments in the treatment of acute right ventricular dysfunction and failure in the perioperative setting. Right ventricular failure, defined as the inability to deliver sufficient blood flow through the pulmonary circulation at normal central venous pressure, is a common problem in the perioperative setting and is associated with an increased mortality. The failure of the right ventricle is caused by reduced right ventricular contractility or an increased right ventricular afterload or both. Recent findings Management of acute right ventricular failure continues to be challenging because of the poor understanding of the pathophysiology, difficulties in diagnosing, the absence of guidelines, and limited therapeutic options. Recent research efforts have led to an improved understanding of the underlying mechanisms and have established a reasonable therapeutic framework. Summary Right ventricular dysfunction may cause venous congestion and systemic hypoperfusion. After identifying right ventricular dysfunction, the primary goal is to correct reversible causes of excessive load or reduced right-ventricular contractility. If the underlying abnormalities cannot be reversed, diuretic, vasodilator, or inotropic therapy may be required.
引用
收藏
页码:388 / 393
页数:6
相关论文
共 34 条
[1]   Pulmonary hypertension [J].
Beuckelmann, DJ .
INTERNIST, 1997, 38 (10) :1020-1033
[2]   The Right Ventricle Under Pressure Cellular and Molecular Mechanisms of Right-Heart Failure in Pulmonary Hypertension [J].
Bogaard, Harm J. ;
Abe, Kohtaro ;
Noordegraaf, Anton Vonk ;
Voelkel, Norbert F. .
CHEST, 2009, 135 (03) :794-804
[3]   Effect of reperfusion on biventricular function and survival after right ventricular infarction [J].
Bowers, TR ;
O'Neill, WW ;
Grines, C ;
Pica, MC ;
Safian, RD ;
Goldstein, JA .
NEW ENGLAND JOURNAL OF MEDICINE, 1998, 338 (14) :933-940
[4]   PERFORMANCE OF RIGHT VENTRICLE UNDER STRESS - RELATION TO RIGHT COROONARY FLOW [J].
BROOKS, H ;
KIRK, ES ;
VOKONAS, PS ;
URSCHEL, CW ;
SONNENBLICK, EH .
JOURNAL OF CLINICAL INVESTIGATION, 1971, 50 (10) :2176-+
[5]   Activation of apoptotic pathways in experimental acute afterload-induced right ventricular failure [J].
Dewachter, Celine ;
Dewachter, Laurence ;
Rondelet, Benoit ;
Fesler, Pierre ;
Brimioulle, Serge ;
Kerbaul, Francois ;
Naeije, Robert .
CRITICAL CARE MEDICINE, 2010, 38 (06) :1405-1413
[6]   NEGATIVE INOTROPIC EFFECTS OF CYTOKINES ON THE HEART MEDIATED BY NITRIC-OXIDE [J].
FINKEL, MS ;
ODDIS, CV ;
JACOB, TD ;
WATKINS, SC ;
HATTLER, BG ;
SIMMONS, RL .
SCIENCE, 1992, 257 (5068) :387-389
[7]   VOLUME EXPANSION VERSUS NOREPINEPHRINE IN TREATMENT OF A LOW CARDIAC-OUTPUT COMPLICATING AN ACUTE INCREASE IN RIGHT VENTRICULAR AFTERLOAD IN DOGS [J].
GHIGNONE, M ;
GIRLING, L ;
PREWITT, RM .
ANESTHESIOLOGY, 1984, 60 (02) :132-135
[8]   Calpain inhibition attenuates right ventricular contractile dysfunction after acute pressure overload [J].
Greyson, Clifford R. ;
Schwartz, Gregory G. ;
Lu, Li ;
Ye, Shuyu ;
Helmke, Steve ;
Xu, Ya ;
Ahmad, Hasan .
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY, 2008, 44 (01) :59-68
[9]   Right heart failure in the intensive care unit [J].
Greyson, Clifford R. .
CURRENT OPINION IN CRITICAL CARE, 2012, 18 (05) :424-431
[10]  
Greyson Clifford R, 2008, Crit Care Med, V36, pS57, DOI 10.1097/01.CCM.0000296265.52518.70