Novel Perfluoroalkyl Ether Carboxylic Acids (PFECAs) and Sulfonic Acids (PFESAs): Occurrence and Association with Serum Biochemical Parameters in Residents Living Near a Fluorochemical Plant in China

被引：120

作者：

Yao, Jingzhi ^{[1
]}

Pan, Yitao ^{[1
]}

Sheng, Nan ^{[1
]}

Su, Zhaoben ^{[2
]}

Guo, Yong ^{[2
]}

Wang, Jianshe ^{[1
]}

Dai, Jiayin ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Zool, Key Lab Anim Ecol & Conservat Biol, Beijing 100101, Peoples R China

[2] Chinese Acad Sci, Key Lab Organofluorine Chem, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China

来源：

ENVIRONMENTAL SCIENCE & TECHNOLOGY | 2020年 / 54卷 / 21期

基金：

中国国家自然科学基金;

关键词：

Although perfluoroalkyl ether carboxylic (PFECAs) and sulfonic acids (PFESAs) have been widely detected in environmental matrices; their occurrence in humans and impact on human health remains insufficiently understood. Here; we report on 13 PFECAs and PFESAs in 977 sera samples collected from residents living near a fluorochemical plant in Shandong; China. The sum concentration of these emerging PFECAs accounted for 13% of the total PFASs in the serum of the participants; with the frequent detection of several PFECAs (>95%) (PFMOAA; PFO4DA; and PFO5DoDA at median concentrations of 12.91; 0.142; and; 0.987; ng/mL; respectively) and PFESAs (98.7%) (Nafion byproduct 2 at a median concentration of 0.097 ng/mL). Serum PFMOAA; PFO5DoDA; and 6:2 Cl-PFESA levels were significantly higher in males than in females. Positive relationships were observed between age and PFMOAA; 6:2; Cl-PFESA; and H-PFMO2OSA levels; whereas HFPO-TA and PFO5DoDA serum concentrations in the 0-40-year age group were lower than that in the >40-year age group. Furthermore; multivariate linear regression models and sensitivity analyses showed positive associations among PFO5DoDA levels; elevated lipid parameters (cholesterol; low-density lipoprotein cholesterol; and triglycerides); liver function markers (albumin levels and alanine transaminase; aspartate aminotransferase; and glutamyl transpeptidase activities); and uric acid levels. Thus; our results suggest potential health risks from exposure to novel PFESAs and PFECAs (especially PFO5DoDA). ©;

D O I：

10.1021/acs.est.0c02888

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Although perfluoroalkyl ether carboxylic (PFECAs) and sulfonic acids (PFESAs) have been widely detected in environmental matrices, their occurrence in humans and impact on human health remains insufficiently understood. Here, we report on 13 PFECAs and PFESAs in 977 sera samples collected from residents living near a fluorochemical plant in Shandong, China. The sum concentration of these emerging PFECAs accounted for 13% of the total PFASs in the serum of the participants, with the frequent detection of several PFECAs (>95%) (PFMOAA, PFO4DA, and PFO5DoDA at median concentrations of 12.91, 0.142, and 0.987 ng/mL, respectively) and PFESAs ( 98.7%) (Nafion byproduct 2 at a median concentration of 0.097 ng/mL). Serum PFMOAA, PFO5DoDA, and 6:2 Cl-PFESA levels were significantly higher in males than in females. Positive relationships were observed between age and PFMOAA, 6:2 Cl-PFESA, and H-PFMO2OSA levels, whereas HFPO-TA and PFO5DoDA serum concentrations in the 0-40-year age group were lower than that in the >40-year age group. Furthermore, multivariate linear regression models and sensitivity analyses showed positive associations among PFO5DoDA levels, elevated lipid parameters (cholesterol, low-density lipoprotein cholesterol, and triglycerides), liver function markers (albumin levels and alanine transaminase, aspartate aminotransferase, and glutamyl transpeptidase activities), and uric acid levels. Thus, our results suggest potential health risks from exposure to novel PFESAs and PFECAs (especially PFO5DoDA).

引用

页码：13389 / 13398

页数：10

共 55 条

[41] Human Exposure and Elimination Kinetics of Chlorinated Polyfluoroalkyl Ether Sulfonic Acids (Cl-PFESAs) [J].