Serotonin transporter gene and stress reactivity in unipolar depression

被引：3

作者：

Welper, H. ^{[1
,2
]}

Aller, A. ^{[1
]}

Guttenthaler, V. ^{[1
]}

Hoefels, S. ^{[1
]}

Lennertz, L. ^{[1
]}

Pfeiffer, U. ^{[1
]}

Schwab, S. G. ^{[1
,3
]}

Zobel, A. ^{[1
]}

机构：

[1] Univ Klinikum Bonn, Klin & Poliklin Psychiat & Psychotherapie, Bonn, Germany

[2] Univ Leipzig, Klin Psychiat & Psychotherapie Kindes & Jugendalt, D-04109 Leipzig, Germany

[3] Univ Erlangen Nurnberg, Psychiat & Psychotherapeut Klin, Erlangen, Germany

来源：

NERVENARZT | 2014年 / 85卷 / 03期

关键词：

Depression; Endophenotype; Serotonin transporter gene; Hypothalamic-pituitary-adrenal axis; Dexamethasone-corticotropin-releasing hormone test; LINKED POLYMORPHIC REGION; PROMOTER POLYMORPHISM; LIFE EVENTS; 5-HTT GENE; ASSOCIATION; CORTISOL; DISORDER; ENDOPHENOTYPES; ADOLESCENTS; MODERATION;

D O I：

10.1007/s00115-012-3702-7

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

A length polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) is associated with both depression and hypothalamic-pituitary-adrenal (HPA) system activity. A dysregulation of the HPA system is considered to be a candidate endophenotype of depression. The objective of the present study was an investigation of a possible gene-endophenotype-interaction between 5-HTTLPR and HPA system activity in a sample of inpatients with major depression. A total of 237 inpatients with major depression were genotyped for 5-HTTLPR and participated in a combined dexamethasone-corticotropin-releasing hormone test (Dex-CRH test) as well as using the Hamilton score (Hamilton rating scale for depression) to determine the severity of the psychopathology. Patients with the ss-genotype showed a significantly higher HPA -system activity in comparison to patients with the lI-genotype, but no association between 5-HTTLPR and the severity of psychopathology could be detected. The results of the current study demonstrate an influence of 5-HTTLPR on dysregulation of the HPA system in patients with major depression and support the hypothesis that 5-HTTLPR- and HPA-system-interaction constitutes an important component in the pathogenesis of depression.

引用

页码：336 / +

页数：7