Poly(carbonate urethane)-Based Thermogels with Enhanced Drug Release Efficacy for Chemotherapeutic Applications

被引：36
作者：
Chan, Benjamin Qi Yu [1 ,2 ]
Cheng, Hongwei [3 ]
Liow, Sing Shy [1 ]
Dou, Qingqing [1 ]
Wu, Yun-Long [3 ]
Loh, Xian Jun [1 ,2 ,4 ]
Li, Zibiao [1 ]
机构：
[1] ASTAR, IMRE, 2 Fusionopolis Way,08-03 Innovis, Singapore 138634, Singapore
[2] Natl Univ Singapore, Dept Mat Sci & Engn, 9,Engn Dr 1, Singapore 117575, Singapore
[3] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China
[4] Singapore Eye Res Inst, 11 Third Hosp Ave, Singapore 168751, Singapore
来源：
POLYMERS | 2018年 / 10卷 / 01期
基金：
中国国家自然科学基金;
关键词：
in-situ hydrogel; thermo-responsive polymers; drug release; cancer therapy; POLY(ESTER URETHANE)S; BLOCK-COPOLYMERS; POLY(ETHYLENE GLYCOL); TRIBLOCK COPOLYMERS; HYDROGELS; DELIVERY; MICELLIZATION; GELATION; THERMODYNAMICS; DEGRADATION;
D O I：
10.3390/polym10010089
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this study, we report the synthesis and characterisation of a thermogelling poly(carbonate urethane) system comprising poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG) and poly(polytetrahydrofuran carbonate) (PTHF carbonate). The incorporation of PTHF carbonate allowed for the control of the lower critical solution temperature (LCST) and decreased critical gelation concentration (CGC) of the thermogels significantly. In addition, the as-prepared thermogels displayed low toxicity against HepG2, L02 and HEK293T cells. Drug release studies were carried out using doxorubicin (Dox). Studies conducted using nude mice models with hepatocellular carcinoma revealed that the Dox-loaded poly(PEG/PPG/PTHF carbonate urethane) thermogels showed excellent in vivo anti-tumour performance and effectively inhibited tumour growth in the tested model.
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页数：16
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