Poly(carbonate urethane)-Based Thermogels with Enhanced Drug Release Efficacy for Chemotherapeutic Applications

被引：36
作者：
Chan, Benjamin Qi Yu [1 ,2 ]
Cheng, Hongwei [3 ]
Liow, Sing Shy [1 ]
Dou, Qingqing [1 ]
Wu, Yun-Long [3 ]
Loh, Xian Jun [1 ,2 ,4 ]
Li, Zibiao [1 ]
机构：
[1] ASTAR, IMRE, 2 Fusionopolis Way,08-03 Innovis, Singapore 138634, Singapore
[2] Natl Univ Singapore, Dept Mat Sci & Engn, 9,Engn Dr 1, Singapore 117575, Singapore
[3] Xiamen Univ, Sch Pharmaceut Sci, Fujian Prov Key Lab Innovat Drug Target Res, Xiamen 361102, Peoples R China
[4] Singapore Eye Res Inst, 11 Third Hosp Ave, Singapore 168751, Singapore
来源：
POLYMERS | 2018年 / 10卷 / 01期
基金：
中国国家自然科学基金;
关键词：
in-situ hydrogel; thermo-responsive polymers; drug release; cancer therapy; POLY(ESTER URETHANE)S; BLOCK-COPOLYMERS; POLY(ETHYLENE GLYCOL); TRIBLOCK COPOLYMERS; HYDROGELS; DELIVERY; MICELLIZATION; GELATION; THERMODYNAMICS; DEGRADATION;
D O I：
10.3390/polym10010089
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
In this study, we report the synthesis and characterisation of a thermogelling poly(carbonate urethane) system comprising poly(ethylene glycol) (PEG), poly(propylene glycol) (PPG) and poly(polytetrahydrofuran carbonate) (PTHF carbonate). The incorporation of PTHF carbonate allowed for the control of the lower critical solution temperature (LCST) and decreased critical gelation concentration (CGC) of the thermogels significantly. In addition, the as-prepared thermogels displayed low toxicity against HepG2, L02 and HEK293T cells. Drug release studies were carried out using doxorubicin (Dox). Studies conducted using nude mice models with hepatocellular carcinoma revealed that the Dox-loaded poly(PEG/PPG/PTHF carbonate urethane) thermogels showed excellent in vivo anti-tumour performance and effectively inhibited tumour growth in the tested model.
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页数：16
相关论文
共 59 条
[1]   MICELLIZATION OF POLY(ETHYLENE OXIDE)-POLY(PROPYLENE OXIDE)-POLY(ETHYLENE OXIDE) TRIBLOCK COPOLYMERS IN AQUEOUS-SOLUTIONS - THERMODYNAMICS OF COPOLYMER ASSOCIATION [J].
ALEXANDRIDIS, P ;
HOLZWARTH, JF ;
HATTON, TA .
MACROMOLECULES, 1994, 27 (09) :2414-2425
[2]  
Ang J. Y., 2017, MACROMOL MATER ENG, P302
[3]   Supramolecular polymeric hydrogels [J].
Appel, Eric A. ;
del Barrio, Jesus ;
Loh, Xian Jun ;
Scherman, Oren A. .
CHEMICAL SOCIETY REVIEWS, 2012, 41 (18) :6195-6214
[4]   Thermogelling poly(caprolactone-b-ethylene glycol-b-caprolactone) aqueous solutions [J].
Bae, SJ ;
Suh, JM ;
Sohn, YS ;
Bae, YH ;
Kim, SW ;
Jeong, B .
MACROMOLECULES, 2005, 38 (12) :5260-5265
[5]   New Linear and Star-Shaped Thermogelling Poly([R]-3-hydroxybutyrate) Copolymers [J].
Barouti, Ghislaine ;
Liow, Sing Shy ;
Dou, Qingqing ;
Ye, Hongye ;
Orione, Clement ;
Guillaume, Sophie M. ;
Loh, Xian Jun .
CHEMISTRY-A EUROPEAN JOURNAL, 2016, 22 (30) :10501-10512
[6]   Dual-responsive hybrid thermoplastic shape memory polyurethane [J].
Chan, Benjamin Qi Yu ;
Heng, Sylvester Jun Wen ;
Liow, Sing Shy ;
Zhang, Kangyi ;
Loh, Xian Jun .
MATERIALS CHEMISTRY FRONTIERS, 2017, 1 (04) :767-779
[7]   Recent Advances in Shape Memory Soft Materials for Biomedical Applications [J].
Chan, Benjamin Qi Yu ;
Low, Zhi Wei Kenny ;
Heng, Sylvester Jun Wen ;
Chan, Siew Yin ;
Owh, Cally ;
Loh, Xian Jun .
ACS APPLIED MATERIALS & INTERFACES, 2016, 8 (16) :10070-10087
[8]   Organic-inorganic shape memory thermoplastic polyurethane based on polycaprolactone and polydimethylsiloxane [J].
Chan, Benjamin Qi Yu ;
Liow, Sing Shy ;
Loh, Xian Jun .
RSC ADVANCES, 2016, 6 (41) :34946-34954
[9]   Electrospun Pectin-Polyhydroxybutyrate Nanofibers for Retinal Tissue Engineering [J].
Chan, Siew Yin ;
Chan, Benjamin Qi Yu ;
Liu, Zengping ;
Parikh, Bhav Harshad ;
Zhang, Kangyi ;
Lin, Qianyu ;
Su, Xinyi ;
Kai, Dan ;
Choo, Wee Sim ;
Young, David James ;
Loh, Xian Jun .
ACS OMEGA, 2017, 2 (12) :8959-8968
[10]   Thixotropic Supramolecular Pectin-Poly(Ethylene Glycol) Methacrylate (PEGMA) Hydrogels [J].
Chan, Siew Yin ;
Choo, Wee Sim ;
Young, David James ;
Loh, Xian Jun .
POLYMERS, 2016, 8 (11)
123456