Cochlear gene therapy: current perspectives

被引：3

作者：

Wareing, MJ ^{[1
]}

Lalwani, AK ^{[1
]}

机构：

[1] Univ Calif San Francisco, Epstein Labs, Dept Otolaryngol Head & Neck Surg, Mol Oncol Lab, San Francisco, CA 94143 USA

来源：

INTERNATIONAL JOURNAL OF PEDIATRIC OTORHINOLARYNGOLOGY | 1999年 / 49卷

关键词：

adeno-associated virus; cochlea; gene therapy; hearing impairment;

D O I：

10.1016/S0165-5876(99)00127-5

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 ;

摘要：

Gene therapy has the potential to revolutionize therapy for hearing disorders. Advances in our understanding of the molecular basis of hearing combined with techniques for intracochlear gene transfer are leading us closer to clinical applications. Potential areas of interest are reviewed and experimental success using adeno-associated virus to effect intracochlear gene transfer is discussed. (C) 1999 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：S27 / S30

页数：4

共 18 条

[1] REGENERATION OF THE TECTORIAL MEMBRANE IN THE CHICK COCHLEA FOLLOWING SEVERE ACOUSTIC TRAUMA [J].

COTANCHE, DA .

HEARING RESEARCH, 1987, 30 (2-3) :197-206

[2]

DAVIES E, 1994, AM J OTOL, V15, P757

[3] RESTORATION OF BRAIN-STEM AUDITORY-EVOKED POTENTIALS BY GENE-TRANSFER IN SHIVERER MICE [J].

FUJIYOSHI, T ;

HOOD, L ;

YOO, TJ .

ANNALS OF OTOLOGY RHINOLOGY AND LARYNGOLOGY, 1994, 103 (06) :449-456

[4] Defective HSV-1 vector expressing BDNF in auditory ganglia elicits neurite outgrowth: Model for treatment of neuron loss following cochlear degeneration [J].

Geschwind, MD ;

Hartnick, CJ ;

Liu, W ;

Amat, J ;

VandeWater, TR ;

Federoff, HJ .

HUMAN GENE THERAPY, 1996, 7 (02) :173-182

[5]

Gorlin R, 1995, GENETIC DEAFNESS ITS

[6] Transgene expression in the guinea pig cochlea mediated by a lentivirus-derived gene transfer vector [J].

Han, JJ ;

Mhatre, AN ;

Wareing, M ;

Pettis, R ;

Gao, WQ ;

Zufferey, RN ;

Trono, D ;

Lalwani, AK .

HUMAN GENE THERAPY, 1999, 10 (11) :1867-1873

[7]

HAN JJ, 1997, J AUDIOL MED, V6, P105

[8] LONG-TERM GENE-EXPRESSION AND PHENOTYPIC CORRECTION USING ADENOASSOCIATED VIRUS VECTORS IN THE MAMMALIAN BRAIN [J].

KAPLITT, MG ;

LEONE, P ;

SAMULSKI, RJ ;

XIAO, X ;

PFAFF, DW ;

OMALLEY, KL ;

DURING, MJ .

NATURE GENETICS, 1994, 8 (02) :148-154

[9] Long-term in vivo cochlear transgene expression mediated by recombinant adeno-associated virus [J].

Lalwani, AK ;

Walsh, BJ ;

Reilly, PG ;

Carvalho, GJ ;

Zolotukhin, S ;

Muzyczka, N ;

Mhatre, AN .

GENE THERAPY, 1998, 5 (02) :277-281

[10]

Lalwani AK, 1996, GENE THER, V3, P588

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