Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's disease

被引：11

作者：

Zhou, Xin ^{[1
]}

Yang, Chun ^{[1
]}

Liu, Yufeng ^{[1
]}

Li, Peng ^{[1
]}

Yang, Huiying ^{[1
]}

Dai, Jingxing ^{[1
]}

Qu, Rongmei ^{[1
]}

Yuan, Lin ^{[1
]}

机构：

[1] Southern Med Univ, Sch Basic Med Sci, Dept Human Anat Histol & Embryol, Guangzhou 510515, Guangdong, Peoples R China

来源：

NEURAL REGENERATION RESEARCH | 2014年 / 9卷 / 01期

关键词：

nerve regeneration; lipid rafts; amyloid precursor protein; autophagy; lysosome; Alzheimer's disease; Two-system Theory; amyloid beta peptide; autophagosome; National Financial Major Project of China; neural regeneration; BLOOD-BRAIN-BARRIER; PRECURSOR PROTEIN; NEURODEGENERATIVE DISEASE; CONNECTIVE TISSUES; OXIDATIVE STRESS; APOLIPOPROTEIN-E; PLASMA-MEMBRANE; GM1; GANGLIOSIDE; GAMMA-SECRETASE; MOUSE MODEL;

D O I：

10.4103/1673-5374.125335

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Amyloid-beta peptide is the main component of amyloid plaques, which are found in Alzheimer's disease. The generation and deposition of amyloid-beta is one of the crucial factors for the onset and progression of Alzheimer's disease. Lipid rafts are glycolipid-rich liquid domains of the plasma membrane, where certain types of protein tend to aggregate and intercalate. Lipid rafts are involved in the generation of amyloid-beta oligomers and the formation of amyloid-beta peptides. In this paper, we review the mechanism by which lipid rafts disturb the aberrant degradative autophagic-lysosomal pathway of amyloid-beta, which plays an important role in the pathological process of Alzheimer's disease. Moreover, we describe this mechanism from the view of the Two-system Theory of fasciology and thus, suggest that lipid rafts may be a new target of Alzheimer's disease treatment.

引用

页码：92 / 100

页数：9

共 117 条

[1] Up-regulation of the lysosomal system in experimental models of neuronal injury: Implications for Alzheimer's disease [J].