Biological evaluation of two potent inhibitors of Trypanosoma cruzi epimastigotes against the intracellular form of the parasite

被引：12

作者：

Rodriguez, JB ^{[1
]}

Zhong, L ^{[1
]}

Docampo, R ^{[1
]}

Gros, EG ^{[1
]}

机构：

[1] UNIV ILLINOIS,COLL VET MED,DEPT VET PATHOBIOL,URBANA,IL 61801

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 22期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0960-894X(96)00517-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

(+/-)-S-Ethyl-[3,7,11]-trimethyl-10,11-epoxy-2E,6E-dien-1-yl]-thioicarbonate (1) and 4-phenoxyphenoxy ethyl tetrahydropyranyl ether (2) were shown to be very active antireplicative agents against intracellular Trypanosoma cruzi amastigotes in in vitro assays. Both of them had previously presented high biological activity as growth inhibitors of the epimastigote form of the parasite. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：2783 / 2786

页数：4

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