Copper-Catalyzed Carboxamide-Directed Ortho Amination of Anilines with Alkylamines at Room Temperature

被引：179

作者：

Li, Qiong ^{[1
]}

Zhang, Shu-Yu ^{[1
]}

He, Gang ^{[1
]}

Ai, Zhaoyan ^{[1
]}

Nack, William A. ^{[1
]}

Chen, Gong ^{[1
]}

机构：

[1] Penn State Univ, Dept Chem, University Pk, PA 16802 USA

来源：

ORGANIC LETTERS | 2014年 / 16卷 / 06期

基金：

美国国家科学基金会;

关键词：

C-H BONDS; UNACTIVATED C(SP(3))-H; C(SP(2))-H BONDS; PALLADIUM; ARYLATION; FUNCTIONALIZATION; ALKOXYLATION; ALKYLATION; COMPLEXES; OXIDATION;

D O I：

10.1021/ol500464x

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

In this report, a highly efficient method for the room temperature installation of alkyl amino motifs onto the ortho position of anilines via Cu-catalyzed carboxamide-directed amination with alkylamines is described. This method offers a practical solution for the rapid synthesis of complex arylamines from simple starting materials and enables new planning strategies for the construction of arylamine-containing pharmacophores. A single electron transfer (SET)-mediated mechanism is proposed.

引用

页码：1764 / 1767

页数：4

共 52 条

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