The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells

被引：10

作者：

Zou, Xueyang ^{[1
]}

Sun, Guangyu ^{[1
]}

Huo, Feifei ^{[1
]}

Chang, Lu ^{[1
]}

Yang, Wei ^{[1
]}

机构：

[1] Jilin Univ, Dept Immunol, Coll Basic Med Sci, Changchun 130021, Jilin, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2018年 / 2018卷

基金：

中国国家自然科学基金;

关键词：

OX40; LIGAND; IN-VIVO; ICOS; RECEPTOR; INDUCTION; PROMOTE; IL-27; DEFICIENCY; ACTIVATION; EXPRESSION;

D O I：

10.1155/2018/7281453

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T follicular helper cells (T-FH) are a subset of recently discovered CD4(+) T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of T-FH cells are clear. However, the early differentiation of these cells is not clear. Dendritic cells (DCs) participate in the differentiation of T-FH cells. Therefore, this article reviewed the research progress regarding the influence of DCs on the differentiation of T-FH cells and their major underlying mechanisms.

引用

页数：7

共 50 条

[41] CD8α- Dendritic Cells Induce Antigen-Specific T Follicular Helper Cells Generating Efficient Humoral Immune Responses [J].

Shin, Changsik ;

Han, Jae-A ;

Koh, Hyein ;

Choi, Bongseo ;

Cho, Yongbin ;

Jeong, Hyeongmin ;

Ra, Jea-Sun ;

Sung, Pil Soo ;

Shin, Eui-Cheol ;

Ryu, Seongho ;

Do, Yoonkyung .

CELL REPORTS, 2015, 11 (12) :1929-1940

[42] Human T follicular helper (Tfh) cells and disease [J].

Ma, Cindy S. ;

Deenick, Elissa K. .

IMMUNOLOGY AND CELL BIOLOGY, 2014, 92 (01) :64-71

[43] T follicular helper and memory B cells in IgE recall responses [J].

Koenig, Joshua F. E. .

ALLERGOLOGY INTERNATIONAL, 2025, 74 (01) :4-12

[44] The origins, function, and regulation of T follicular helper cells [J].

Ma, Cindy S. ;

Deenick, Elissa K. ;

Batten, Marcel ;

Tangye, Stuart G. .

JOURNAL OF EXPERIMENTAL MEDICINE, 2012, 209 (07) :1241-1253

[45] Human T follicular helper cells in primary immunodeficiencies [J].

Ma, Cindy S. ;

Uzel, Gulbu ;

Tangye, Stuart G. .

CURRENT OPINION IN PEDIATRICS, 2014, 26 (06) :720-726

[46] Follicular helper T cells in type 1 diabetes [J].

Shao, Feng ;

Zheng, Peilin ;

Yu, Di ;

Zhou, Zhiguang ;

Jia, Lijing .

FASEB JOURNAL, 2020, 34 (01) :30-40

[47] Human T Follicular Helper Cells: Development and Subsets [J].

Schmitt, Nathalie ;

Ueno, Hideki .

CROSSROADS BETWEEN INNATE AND ADAPTIVE IMMUNITY IV, 2013, 785 :87-94

[48] The E3 ubiquitin ligase Itch is required for the differentiation of follicular helper T cells [J].

Xiao, Nengming ;

Eto, Danelle ;

Elly, Chris ;

Peng, Guiying ;

Crotty, Shane ;

Liu, Yun-Cai .

NATURE IMMUNOLOGY, 2014, 15 (07) :657-666

[49] Mesenchymal Stromal Cells Support the Viability and Differentiation of Follicular Lymphoma-Infiltrating Follicular Helper T-Cells [J].

Brady, Michael T. ;

Hilchey, Shannon P. ;

Hyrien, Ollivier ;

Spence, Stephen A. ;

Bernstein, Steven H. .

PLOS ONE, 2014, 9 (05)

[50] Role of T Follicular Helper Cells in Viral Infections and Vaccine Design [J].

Ahmadivand, Sohrab ;

Fux, Robert ;

Palic, Dusan .

CELLS, 2025, 14 (07)

← 1 2 3 4 5 →