The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells

被引：10

作者：

Zou, Xueyang ^{[1
]}

Sun, Guangyu ^{[1
]}

Huo, Feifei ^{[1
]}

Chang, Lu ^{[1
]}

Yang, Wei ^{[1
]}

机构：

[1] Jilin Univ, Dept Immunol, Coll Basic Med Sci, Changchun 130021, Jilin, Peoples R China

来源：

JOURNAL OF IMMUNOLOGY RESEARCH | 2018年 / 2018卷

基金：

中国国家自然科学基金;

关键词：

OX40; LIGAND; IN-VIVO; ICOS; RECEPTOR; INDUCTION; PROMOTE; IL-27; DEFICIENCY; ACTIVATION; EXPRESSION;

D O I：

10.1155/2018/7281453

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

T follicular helper cells (T-FH) are a subset of recently discovered CD4(+) T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of T-FH cells are clear. However, the early differentiation of these cells is not clear. Dendritic cells (DCs) participate in the differentiation of T-FH cells. Therefore, this article reviewed the research progress regarding the influence of DCs on the differentiation of T-FH cells and their major underlying mechanisms.

引用

页数：7

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