The Role of Dendritic Cells in the Differentiation of T Follicular Helper Cells

T follicular helper cells (T-FH) are a subset of recently discovered CD4(+) T cells. Their major function is to participate in the formation of germinal centres (GCs) and promote B cell proliferation and differentiation to play important roles in the production of antibodies. Currently, the functions of T-FH cells are clear. However, the early differentiation of these cells is not clear. Dendritic cells (DCs) participate in the differentiation of T-FH cells. Therefore, this article reviewed the research progress regarding the influence of DCs on the differentiation of T-FH cells and their major underlying mechanisms.