Functional protection of heme-oxygenase-1 enzyme in ischemic and toxic acute kidney injury

被引：5

作者：

Dezoti, Cassiane ^{[1
]}

Watanabe, Mirian ^{[1
]}

Pinto, Carolina Ferreira ^{[1
]}

de Moura Neiva, Luciana Barros ^{[1
]}

Fernandes Vattimo, Maria de Fatima

机构：

[1] Univ Sao Paulo, LEMA, Escola Enfermagem, Sao Paulo, Brazil

来源：

ACTA PAULISTA DE ENFERMAGEM | 2009年 / 22卷

关键词：

kidney/injuries; Heme-oxygenase-1; ACUTE-RENAL-FAILURE; HEME OXYGENASE; RAT-KIDNEY; EXPRESSION; INDUCTION;

D O I：

10.1590/S0103-21002009000800006

中图分类号：

R47 [护理学];

学科分类号：

1011 ;

摘要：

Objective: To investigate the functional protection of heme-oxygenase-1 enzyme (HO-1) when using its inducer (Hemin) and inhibitor (zinc protoporphyrin-ZnPP) in ischemic and toxic acute kidney injury by Polymixin B in mice. Materials: Adult male Wistar mice divided into 8 groups were used: SHAM (control), Ischemic (Isq), Isq+Hemin (Inducer of HO-1), Isq+ZnPP (inhibitor of HO-1), SALINA (control), Polimyxin B (PmxB), PmxB+Hemin, PmxB+ZnPP. Method: Analysis consists of Jaffe (creatinine clearance [crCl]) and FOX-2 (urinary peroxides [UP]). Results: Thirty minutes renal ischemia and its treatment with PmxB reduced the crCl and maintained urinary output. Urinary peroxide levels increased in both injuries. The administration of the inducer of HO-1 resulted in improvement in renal function and reduction in the levels of urinary peroxide. Conclusions: Findings indicated that ischemia and PmxB induce LAR (acute kidney injury [AKI]) by elevating the levels of urinary peroxide. The HO-1 inducer ameliorated the injury in both animal models through redox mechanism.

引用

页码：490 / 493

页数：4

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