Inhibitory Lignans against NFAT transcription factor from Acanthopanax koreanum

被引:43
作者
Cai, XF
Lee, IS
Dat, NT
Shen, GH
Kang, JS
Kim, DH
Kim, YH [1 ]
机构
[1] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea
[2] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea
关键词
Acanthopanax koreanum; araliaceae; lignan; NFAT transcription factor; inhibitory effect;
D O I
10.1007/BF02980142
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Three lignans isolated from the roots of A. koreanum (Araliaceae), namely eleutheroside E (1), tortoside A (2), and hemiariensin (4), were evaluated for their ability to inhibit NFAT transcription factor. Of these compounds, compound 4, possessing a diarylbutane skeleton, exhibited potent inhibitory activity against NFAT transcription factor (IC50: 36.3 +/- 2.5 muM). However, the activities of 1 (IC50: > 500 muM) and 2 (IC50: 136.1 +/- 9.4 muM), which possess bisaryldioxabicyclooctane skeletons, were lower. As the lignan derivatives of the same skeletons, hinokinin (5) and (-)-yatein (6) with diarylbutane skeletons and (+)-syringaresinol (3) with a bisaryldioxabicyclooctane skeleton were also studied for their inhibitory effects on NFAT transcription factor.
引用
收藏
页码:738 / 741
页数:4
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