Reactivity of (2-methylsulfanyl-4-oxo-6-phenyl-4H-pyrimidin-3-yl)-acetic acid methyl ester towards hydrazine hydrate and benzylamine

被引：1

作者：

Burbuliene, Milda M. ^{[1
]}

Dobrovolskaite, Rita ^{[1
]}

Vainilavicius, Povilas ^{[1
]}

机构：

[1] Vilnius State Univ, Dept Organ Chem, Fac Chem, LT-03225 Vilnius, Lithuania

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 2006年 / 43卷 / 06期

关键词：

ANTI-HIV-1; ACTIVITY; ANALOGS; DERIVATIVES; PYRIMIDINE; POTENT;

D O I：

10.1002/jhet.5570430619

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The title ester 1 reacted with hydrazine hydrate to give hydrazide 2, which underwent intramolecular cyclization to yield 1-amino-7-phenyl-1H-imidazo[1,2-a]pyrimidine-2,5-dione (3) or took place in a substitution reaction with benzylamine to form N-benzyl-2-(2-benzylamino-4-oxo-6-phenyl-4H-pyrimidin-3-yl)-acetamide (4). The reaction of ester 1 with benzylamine gave corresponding amide 7, disubstituted derivative 4 or 1-benzyl-7 -phenyl-1H-imidazo [1,2-a]pyrimidine-2,5-dione (8) depending on the reaction conditions.

引用

页码：1557 / 1561

页数：5

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