Timed flat infusion of 5-fluorouracil increases the tolerability of 5-fluorouracil/docetaxel regimen in metastatic breast cancer: a dose-finding study

被引：3
作者：
Ficorella, C
Morelli, MF
Ricevuto, E
Cannita, K
Porzio, G
Baldi, PL
Cianci, G
Di Rocco, ZC
Natoli, C
Tinari, N
De Galitiis, F
Calista, F
Marchetti, P
机构：
[1] Univ Aquila, Dept Expt Med, I-67100 Laquila, Italy
[2] Univ Chieti, Dept Oncol & Neurosci, Sect Med Oncol, Chieti, Italy
来源：
BRITISH JOURNAL OF CANCER | 2004年 / 91卷 / 04期
关键词：
breast cancer; docetaxel; 5-fluorouracil;
D O I：
10.1038/sj.bjc.6601971
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
A dose-finding study was undertaken to determine the maximum-tolerated dose, and the recommended dose of docetaxel in combination with 12-h timed (22:00-10:00) flat infusion of 5-fluorouracil (5-FU) in metastatic breast cancer patients. This schedule seems to reduce the occurrence of stomatitis of the docetaxel and infusional 5-FU regimen.
引用
收藏
页码：618 / 620
页数：3
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