Transformation of cinoxacin by Beauveria bassiana

被引：3

作者：

Parshikov, IA ^{[1
]}

Moody, JD ^{[1
]}

Heinze, TM ^{[1
]}

Freeman, JP ^{[1
]}

Williams, AJ ^{[1
]}

Sutherland, JB ^{[1
]}

机构：

[1] US FDA, Natl Ctr Toxicol Res, Jefferson, AR 72079 USA

来源：

FEMS MICROBIOLOGY LETTERS | 2002年 / 214卷 / 01期

关键词：

antibacterial agent; Beauveria bassiana; biotransformation; cinoxacin;

D O I：

10.1111/j.1574-6968.2002.tb11336.x

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The ability of the fungus Beauveria bassiana ATCC 7159 to transform the antibacterial agent cinoxacin was investigated. Cultures in sucrose-peptone broth were dosed with cinoxacin, grown for 20 days, and then extracted with ethyl acetate, Two metabolites were detected and purified by high-performance liquid chromatography. The major metabolite was identified by mass and proton nuclear magnetic resonance spectra as 1-ethyl-1,4-dihydro-3-(hydroxymethyl)[1,3]dioxolo[4,5-g]cinnolin-4-one and the minor metabolite was identified as 1-ethyl-1,4-diliydro-6,7-diliydroxy-3-(hydroxymethyl)cinnolin-4-one. B, bassiana also reduced quinoline-3-carboxylic acid to 3-(hydroxymethyl)quinoline. (C) 2002 Federation of European Microbiological Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：133 / 136

页数：4

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