IMPAIRED EXPRESSION OF GABA TRANSPORTERS IN THE HUMAN ALZHEIMER'S DISEASE HIPPOCAMPUS, SUBICULUM, ENTORHINAL CORTEX AND SUPERIOR TEMPORAL GYRUS

被引：65

作者：

Fuhrer, Tessa E. ^{[1
]}

Palpagama, Thulani H. ^{[1
]}

Waldvogel, Henry J. ^{[1
]}

Synek, Beth J. L. ^{[1
,2
]}

Turner, Clinton ^{[1
,2
]}

Faull, Richard L. ^{[1
]}

Kwakowsky, Andrea ^{[1
]}

机构：

[1] Univ Auckland, Dept Anat & Med Imaging, Ctr Brain Res, Fac Med & Hlth Sci, Auckland, New Zealand

[2] Auckland City Hosp, Dept Anat Pathol, LabPlus, Auckland, New Zealand

来源：

NEUROSCIENCE | 2017年 / 351卷

关键词：

GABA; GABA transporters; Alzheimer's disease; human brain; PLASMA-MEMBRANE TRANSPORTER; MESSENGER-RNA LOCALIZATION; HUMAN CEREBRAL-CORTEX; NEURONAL LOSS; HUMAN BRAIN; BETAINE/GABA TRANSPORTER; NEUROFIBRILLARY TANGLES; RAT HIPPOCAMPUS; GAT-1; IMMUNOREACTIVITY;

D O I：

10.1016/j.neuroscience.2017.03.041

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the brain and plays an important role in regulating neuronal excitability. GABA reuptake from the synapse is dependent on specific transporters mainly GAT-1, GAT-3 and BGT-1 (GATs). This study is the first to show alterations in the expression of the GATs in the Alzheimer's disease (AD) hippocampus, entorhinal cortex and superior temporal gyrus. We found a significant increase in BGT-1 expression associated with AD in all layers of the dentate gyrus, in the stratum oriens of the CA2 and CA3 and the superior temporal gyrus. In AD there was a significant decrease in GAT-1 expression in the entorhinal cortex and superior temporal gyrus. We also found a significant decrease in GAT-3 immunoreactivity in the stratum pyramidale of the CA1 and CA3, the subiculum and entorhinal cortex. These observations indicate that the expression of the GATs shows brain-region- and layer-specific alterations in AD, suggesting a complex activation pattern of different GATs during the course of the disease. (C) 2017 IBRO. Published by Elsevier Ltd. All rights reserved.

引用

页码：108 / 118

页数：11

共 54 条

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