Leptin Level in Patients with Type 2 Diabetes Mellitus after Fetal Pancreatic Stem Cell Transplant

被引：4
|
作者：
Ulyanova, Olga [1 ]
Taubaldieva, Zhannat [1 ]
Tuganbekova, Saltanat [1 ]
Saparbayev, Samat [2 ]
Kim, Natalya [3 ]
Trimova, Rakhat [1 ]
Kozina, Larissa [3 ]
Shaimardanova, Galiya [4 ]
机构：
[1] Natl Sci Med Res Ctr, Dept Internal Med, Ave Abylay Khan 42, Astana 010009, Kazakhstan
[2] Natl Sci Med Res Ctr, Dept Fetal Cells Transplantat, Astana, Kazakhstan
[3] Natl Sci Med Res Ctr, Dept Clin Lab, Astana, Kazakhstan
[4] Natl Sci Med Res Ctr, Dept Pathomorphol, Astana, Kazakhstan
来源：
EXPERIMENTAL AND CLINICAL TRANSPLANTATION | 2016年 / 14卷
关键词：
C-peptide; Adipokines; Pancreatic islet cell regeneration;
D O I：
10.6002/ect.tondtdtd2016.O22
中图分类号：
R3 [基础医学]; R4 [临床医学];
学科分类号：
1001 ; 1002 ; 100602 ;
摘要：
Objectives: We aimed to determine leptin level in patients with type 2 diabetes mellitus after fetal pancreatic stem cell transplant. Materials and Methods: We examined 14 patients (aged 43-63 years old) with type 2 diabetes mellitus, which we subsequently divided into 2 groups and examined. Group 1 comprised 8 patients who received fetal pancreatic stem cell transplant (cells were 16-18 wk gestation) performed by intravenous infusion; group 2 comprised 6 patients in the control group who were on hypoglycemic tablet therapy or insulin therapy. The quantity of fetal stem cells infused was 5 to 6 x 10(6). We analyzed leptin and C-peptide levels in patients both before and 3 months after the fetal pancreatic stem cell transplant procedure. Results: In patients with type 2 diabetes mellitus, fetal pancreatic stem cell transplant led to a significant increase in leptin levels, from 11.01 ng/mL to 16.29 ng/mL, after 3 months (P < .05). Conclusions: Leptin level increase significantly within 3 months after fetal pancreatic stem cell transplant in patients with type 2 diabetes mellitus.
引用
收藏
页码：45 / 47
页数：3
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