The hidden value of missing genotypes

被引：10
作者：
Amos, William [1 ]
机构：
[1] Univ Cambridge, Dept Zool, Cambridge, England
来源：
MOLECULAR BIOLOGY AND EVOLUTION | 2006年 / 23卷 / 11期
关键词：
human population; microsatellite; null alleles; genetic distance; genotyping error;
D O I：
10.1093/molbev/msl078
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Robotic systems allow vast genetic data sets to be generated automatically with little manual input, raising questions about accuracy. To test whether errors occur randomly, I used the frequencies of missing genotypes in a large human data set to construct a population tree. Remarkably, the gaps appear to carry as strong a phylogenetic signal as the actual data themselves.
引用
收藏
页码：1995 / 1996
页数：2
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