SARS-CoV-2-related Myelin Oligodendrocyte Glycoprotein Antibody-associated Disease: A Case Report and Literature Review

被引：26

作者：

Ide, Toshihiro ^{[1
]}

Kawanami, Takeru ^{[1
]}

Eriguchi, Makoto ^{[1
]}

Hara, Hideo ^{[1
]}

机构：

[1] Saga Univ, Dept Internal Med, Div Neurol, Fac Med, Saga, Japan

来源：

INTERNAL MEDICINE | 2022年 / 61卷 / 08期

关键词：

MOG antibody-associated disease; COVID-19; SARS-CoV-2; optic neuritis; myelitis; demyelinating autoimmune disease; CLINICAL PRESENTATION;

D O I：

10.2169/internalmedicine.8709-21

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We herein report a case of myelin oligodendrocyte glycoprotein (MOG) antibody-associated disease after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. A 24-year-old woman developed unilateral optic neuritis 3 weeks after contracting coronavirus disease 2019 (COVID-19), followed by intracranial demyelinating lesions and myelitis. Since serum anti-MOG antibody was positive, we diagnosed MOG antibody-associated disease. Immunotherapy with steroids resulted in the rapid improvement of neurological symptoms. This is a suggestive case, as there are no reports of MOG antibody-associated disease with multiple neurological lesions occurring after COVID-19. The response to immunotherapy was favorable. This case suggests that it is important to measure anti-MOG antibodies in patients who develop inflammatory neurological disease after COVID-19.

引用

页码：1253 / 1258

页数：6

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