Cardiac sarcoidosis: Diagnosis and therapeutic challenges

被引：7

作者：

Aubart, F. Cohen ^{[1
,2
]}

Nunes, H. ^{[3
]}

Mathian, A. ^{[1
,2
]}

Haroche, J. ^{[1
,2
]}

Hie, M. ^{[1
]}

Boutin, D. Le-Thi Huong ^{[1
,2
]}

Cluzel, P. ^{[2
,4
]}

Soussan, M. ^{[5
]}

Waintraub, X. ^{[6
]}

Fouret, P. ^{[2
,7
]}

Valeyre, D. ^{[3
]}

Amoura, Z. ^{[1
,2
]}

机构：

[1] Grp Hosp Pitie Salpetriere, AP HP, Inst E3M, Serv Med Interne, 47-83 Blvd Hop, F-75651 Paris 13, France

[2] Sorbonne Univ, Univ Paris Pierre & Marie Curie 6, F-75013 Paris, France

[3] Univ Paris XIII, Hop Avicenne, AP HP, Serv Pneumol, F-93000 Bobigny, France

[4] Grp Hosp Pitie Salpetriere, AP HP, Serv Radiol, F-75651 Paris 13, France

[5] Hop Avicenne, AP HP, Nucl Med Serv, F-93000 Bobigny, France

[6] Grp Hosp Pitie Salpetriere, AP HP, Unite Rythmol, Serv Cardiol, F-75651 Paris 13, France

[7] Grp Hosp Pitie Salpetriere, AP HP, Serv Anatomopathol, F-75651 Paris 13, France

来源：

REVUE DE MEDECINE INTERNE | 2017年 / 38卷 / 01期

关键词：

Sarcoidosis; Heart; Rhythm and conduction troubles; Corticosteroids; LOW-CARBOHYDRATE-DIET; ATRIOVENTRICULAR-BLOCK; HEART-TRANSPLANTATION; VENTRICULAR-ARRHYTHMIAS; CORTICOSTEROID-THERAPY; MYOCARDIAL SARCOIDOSIS; DISEASE-ACTIVITY; UNITED-STATES; HIGH-FAT; INVOLVEMENT;

D O I：

10.1016/j.revmed.2016.03.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Sarcoidosis is a granulomatous disorder of unknown cause characterized by non-caseating granuloma in young adults. Cardiac involvement is rare and range from 2 to 75% depending on diagnostic criteria. Cardiac involvement in sarcoidosis may be asymptomatic or may manifest as rhythm/conduction troubles-or congestive heart failure. The diagnosis and treatment of cardiac sarcoidosis may be challenging. However, advances have come in recent years from the use of cardiac MRI and (18)FDG-TEP scanner, as well as from the stratification of the risk of ventricular tachycardia/fibrillation. Due to the rarity of the disease, there is no reliable prospective large study to guide therapeutic strategy for cardiac sarcoidosis. Corticosteroids are probably efficacious, in particular in case of atrio-ventricular block or moderate heart failure. Immunosuppressive drugs have not been largely studied but methotrexate could be helpful. In refractory forms, TNF-alpha antagonists have been used with success. (C) 2016 Societe Nationale Francaise de Medecine Interne (SNFMI). Published by Elsevier Masson SAS. All rights reserved.

引用

页码：28 / 35

页数：8

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