The pharmacogenetics of β2-adrenergic receptors:: Relevance to asthma

被引：61

作者：

Liggett, SB

机构：

[1] Univ Cincinnati, Coll Med, Dept Med, Cincinnati, OH USA

[2] Univ Cincinnati, Coll Med, Dept Mol Genet, Cincinnati, OH USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2000年 / 105卷 / 02期

关键词：

adenylyl cyclase; beta-agonist; tachyphylaxis; pharmacogenetics;

D O I：

10.1016/S0091-6749(00)90048-4

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The beta(2)-adrenergic receptor (beta(2)AR) is the molecular target for beta-agonists used in the treatment of asthma, In the human population, 4 polymorphisms of the beta(2)AR coding block have been found, 3 of which result in receptors that have different properties compared with wild-type. To date, clinical studies suggest that these beta(2)AR polymorphisms may alter asthmatic phenotype and the response to beta-agonist therapy, making these variants the first of undoubtedly several genetic loci that will ultimately be found that will provide for individualized therapy in asthma.

引用

收藏

页码：S487 / S492

页数：6

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